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10.1016/j.hoc.2013.11.004 http://scihub22266oqcxt.onion/10.1016/j.hoc.2013.11.004 C3942790!3942790 !24589273     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24589273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hematol+Oncol+Clin+North+Am 2014 ; 28 (2 ): 387-401 Nephropedia Template TP {{tp|p=24589273 |t=2014. Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches |pdf=|usr=}}{{24589273 }} gab.com Text Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches JO: Hematol Oncol Clin North Am http://www.kidney.de/pget.php?&tw=1&pmid=24589273 #FOAvip In this article, the authors discuss new approaches to treating iron overload diseases using hepcidin mimetics or by modulating endogenous hepcidin expression. In particular, the authors discuss lipid nanoparticle encapsulated siRNA and antisense oligonucleotide-mediated inhibition of TMPRSS6, an upstream regulator of hepcidin, and treatment with transferrin or hepcidin mimetics, including the recently described minihepcidins. In each case, in animal models of ?-thalassemia, not only do the interventions affect iron absorption but they also act as disease-modifying agents that ameliorate the ineffective erythropoiesis. Twit Text FOAVip Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches ????Hematol Oncol Clin North Am http://www.kidney.de/pget.php?&tw=1&pmid=24589273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24589273 #FOAvip English Wikipedia <ref>{{Cite pmid|24589273 }}</ref> Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches #MMPMID24589273 Schmidt PJ ; Fleming MD Hematol Oncol Clin North Am 2014[Apr]; 28 (2 ): 387-401 PMID24589273 show ga In this article, the authors discuss new approaches to treating iron overload diseases using hepcidin mimetics or by modulating endogenous hepcidin expression. In particular, the authors discuss lipid nanoparticle encapsulated siRNA and antisense oligonucleotide-mediated inhibition of TMPRSS6, an upstream regulator of hepcidin, and treatment with transferrin or hepcidin mimetics, including the recently described minihepcidins. In each case, in animal models of ?-thalassemia, not only do the interventions affect iron absorption but they also act as disease-modifying agents that ameliorate the ineffective erythropoiesis. |Animals [MESH] |Disease Models, Animal [MESH] |Gene Expression/drug effects [MESH] |Genistein/pharmacology/therapeutic use [MESH] |Hepcidins/genetics/*metabolism [MESH] |Humans [MESH] |Iron Overload/drug therapy/*metabolism [MESH] |Iron/*metabolism [MESH] |Transferrin/pharmacology/therapeutic use [MESH]Modulation of hepcidin as therapy for primary and secondary iron overl(epmc).pdf DeepDyve Pubget Overpricing