Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1089/ars.2013.5303 http://scihub22266oqcxt.onion/10.1089/ars.2013.5303 C3942678!3942678!23590434     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2014 ; 20 (10): 1618-27 Nephropedia Template TP {{tp|p=23590434|t=2014. Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle |pdf=|usr=}}{{23590434}} gab.com Text Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=23590434 #FOAvip Significance: Manganese superoxide dismutase (MnSOD) is a nuclear-encoded and mitochondria-matrix-localized oxidation-reduction (redox) enzyme that regulates cellular redox homeostasis. Cellular redox processes are known to regulate proliferative and quiescent growth states. Therefore, MnSOD and mitochondria-generated reactive oxygen species (ROS) are believed to be critical regulators of quiescent cells' entry into the cell cycle and exit from the proliferative cycle back to the quiescent state. Recent Advances/Critical Issues: Recent evidence suggests that the intracellular redox environment fluctuates during the cell cycle, shifting toward a more oxidized status during mitosis. MnSOD activity is higher in G0/G1 cells compared with S, G2 and M phases. After cell division, MnSOD activity increases in the G1 phase of the daughter generation. The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption. Based on an inverse correlation between MnSOD activity and glucose consumption during the cell cycle, it is proposed that MnSOD is a central molecular player for the ?Warburg effect.? Future Directions: In general, loss of MnSOD activity results in aberrant proliferation. A better understanding of the MnSOD and mitochondrial ROS-dependent cell cycle processes may lead to novel approaches to overcome aberrant proliferation. Since ROS have both deleterious (pathological) and beneficial (physiological) effects, it is proposed that ?eustress? should be used when discussing ROS processes that regulate normal physiological functions, while ?oxidative stress? should be used to discuss the deleterious effects of ROS. Antioxid. Redox Signal. 20, 1618?1627. Twit Text FOAVip Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=23590434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23590434 #FOAvip English Wikipedia <ref>{{Cite pmid|23590434}}</ref> Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle #MMPMID23590434 Sarsour EH; Kalen AL; Goswami PC Antioxid Redox Signal 2014[Apr]; 20 (10): 1618-27 PMID23590434show ga Significance: Manganese superoxide dismutase (MnSOD) is a nuclear-encoded and mitochondria-matrix-localized oxidation-reduction (redox) enzyme that regulates cellular redox homeostasis. Cellular redox processes are known to regulate proliferative and quiescent growth states. Therefore, MnSOD and mitochondria-generated reactive oxygen species (ROS) are believed to be critical regulators of quiescent cells' entry into the cell cycle and exit from the proliferative cycle back to the quiescent state. Recent Advances/Critical Issues: Recent evidence suggests that the intracellular redox environment fluctuates during the cell cycle, shifting toward a more oxidized status during mitosis. MnSOD activity is higher in G0/G1 cells compared with S, G2 and M phases. After cell division, MnSOD activity increases in the G1 phase of the daughter generation. The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption. Based on an inverse correlation between MnSOD activity and glucose consumption during the cell cycle, it is proposed that MnSOD is a central molecular player for the ?Warburg effect.? Future Directions: In general, loss of MnSOD activity results in aberrant proliferation. A better understanding of the MnSOD and mitochondrial ROS-dependent cell cycle processes may lead to novel approaches to overcome aberrant proliferation. Since ROS have both deleterious (pathological) and beneficial (physiological) effects, it is proposed that ?eustress? should be used when discussing ROS processes that regulate normal physiological functions, while ?oxidative stress? should be used to discuss the deleterious effects of ROS. Antioxid. Redox Signal. 20, 1618?1627. äManganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell(epmc).pdf DeepDyve Pubget Overpricing