Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1319268111 http://scihub22266oqcxt.onion/10.1073/pnas.1319268111 C3939924!3939924!24516163     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (8): 3086-91 Nephropedia Template TP {{tp|p=24516163|t=2014. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist |pdf=|usr=}}{{24516163}} gab.com Text Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24516163 #FOAvip CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 ligand, is a promising immunotherapeutic agent; however, developing an IFN-inducing CpG ODN forming a stable nanoparticle without aggregation has been unsuccessful. Here we generated a nanoparticulate CpG ODN (K3) wrapped by the nonagonistic Dectin-1 ligand schizophyllan (SPG), K3-SPG. K3-SPG stimulates human peripheral blood mononuclear cells to produce large amounts of both type I and II IFN. K3-SPG thus became a potent adjuvant, especially for cytotoxic T-lymphocyte (CTL) induction to coadministered protein antigens without conjugation, which is attributable to its nanoparticulate nature rather than to targeting Dectin-1. Protective potency of K3-SPG as an influenza vaccine adjuvant was demonstrated in both murine and nonhuman primate models. K3-SPG may be used as an IFN inducer as well as a CTL inducer for immunotherapeutic applications. Twit Text FOAVip Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24516163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24516163 #FOAvip English Wikipedia <ref>{{Cite pmid|24516163}}</ref> Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist #MMPMID24516163 Kobiyama K; Aoshi T; Narita H; Kuroda E; Hayashi M; Tetsutani K; Koyama S; Mochizuki S; Sakurai K; Katakai Y; Yasutomi Y; Saijo S; Iwakura Y; Akira S; Coban C; Ishii KJ Proc Natl Acad Sci U S A 2014[Feb]; 111 (8): 3086-91 PMID24516163show ga CpG oligodeoxynucleotide (ODN), a Toll-like receptor 9 ligand, is a promising immunotherapeutic agent; however, developing an IFN-inducing CpG ODN forming a stable nanoparticle without aggregation has been unsuccessful. Here we generated a nanoparticulate CpG ODN (K3) wrapped by the nonagonistic Dectin-1 ligand schizophyllan (SPG), K3-SPG. K3-SPG stimulates human peripheral blood mononuclear cells to produce large amounts of both type I and II IFN. K3-SPG thus became a potent adjuvant, especially for cytotoxic T-lymphocyte (CTL) induction to coadministered protein antigens without conjugation, which is attributable to its nanoparticulate nature rather than to targeting Dectin-1. Protective potency of K3-SPG as an influenza vaccine adjuvant was demonstrated in both murine and nonhuman primate models. K3-SPG may be used as an IFN inducer as well as a CTL inducer for immunotherapeutic applications. äNonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparti(epmc).pdf DeepDyve Pubget Overpricing