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10.1016/j.canlet.2013.08.014 http://scihub22266oqcxt.onion/10.1016/j.canlet.2013.08.014 C3935998!3935998!23988267     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2014 ; 345 (2): 164-73 Nephropedia Template TP {{tp|p=23988267|t=2014. Molecular mechanisms underlying chronic inflammation-associated cancers |pdf=|usr=}}{{23988267}} gab.com Text Molecular mechanisms underlying chronic inflammation-associated cancers JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=23988267 #FOAvip Although it is now accepted that chronic inflammation plays an essential role in tumorigenesis, the underlying molecular mechanisms linking inflammation and cancer remain to be fully explored. Inflammatory mediators present in the tumor microenvironment, including cytokines and growth factors, as well as reactive oxygen species (ROS) and reactive nitrogen species (RNS), have been implicated in the etiology of inflammation-associated cancers. Epithelial NADPH oxidase (Nox) family proteins, which generate ROS regulated by cytokines, are upregulated during chronic inflammation and cancer. ROS serve as effector molecules participating in host defense or as chemo-attractants recruiting leukocytes to wounds, thereby influencing the inflammatory reaction in damaged tissues. ROS can alter chromosomal DNA, leading to genomic instability, and may serve as signaling molecules that affect tumor cell proliferation, survival, metabolism, angiogenesis, and metastasis. Targeting Noxs and their downstream signaling components may be a promising approach to pre-empting inflammation-related malignancies. Twit Text FOAVip Molecular mechanisms underlying chronic inflammation-associated cancers ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=23988267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23988267 #FOAvip English Wikipedia <ref>{{Cite pmid|23988267}}</ref> Molecular mechanisms underlying chronic inflammation-associated cancers #MMPMID23988267 Wu Y; Antony S; Meitzler JL; Doroshow JH Cancer Lett 2014[Apr]; 345 (2): 164-73 PMID23988267show ga Although it is now accepted that chronic inflammation plays an essential role in tumorigenesis, the underlying molecular mechanisms linking inflammation and cancer remain to be fully explored. Inflammatory mediators present in the tumor microenvironment, including cytokines and growth factors, as well as reactive oxygen species (ROS) and reactive nitrogen species (RNS), have been implicated in the etiology of inflammation-associated cancers. Epithelial NADPH oxidase (Nox) family proteins, which generate ROS regulated by cytokines, are upregulated during chronic inflammation and cancer. ROS serve as effector molecules participating in host defense or as chemo-attractants recruiting leukocytes to wounds, thereby influencing the inflammatory reaction in damaged tissues. ROS can alter chromosomal DNA, leading to genomic instability, and may serve as signaling molecules that affect tumor cell proliferation, survival, metabolism, angiogenesis, and metastasis. Targeting Noxs and their downstream signaling components may be a promising approach to pre-empting inflammation-related malignancies. äMolecular mechanisms underlying chronic inflammation-associated cancer(epmc).pdf DeepDyve Pubget Overpricing