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10.1016/j.jaci.2013.06.037 http://scihub22266oqcxt.onion/10.1016/j.jaci.2013.06.037 C3935986!3935986!23987798     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2014 ; 133 (4): 1195-1202.e2 Nephropedia Template TP {{tp|p=23987798|t=2014. Marked and persistent eosinophilia in the absence of clinical manifestations |pdf=|usr=}}{{23987798}} gab.com Text Marked and persistent eosinophilia in the absence of clinical manifestations JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23987798 #FOAvip Background: Although most patients with hypereosinophilic syndromes (HES) present with clinical signs and symptoms attributable to eosinophilic tissue infiltration, some untreated patients remain asymptomatic or have signs and symptoms, such as allergic rhinitis, for which the relationship to peripheral eosinophilia is unclear (hypereosinophilia of unknown significance [HEUS]). Objective: To identify and characterize subjects with HEUS of 5 years duration or more as compared to untreated patients with symptomatic HES and healthy normal volunteers. Methods: All subjects with eosinophilia underwent yearly evaluation, including a standardized clinical evaluation, whole blood flow cytometry to assess lymphocyte subsets and eosinophil activation, and serum collection. Peripheral blood mononuclear cells were cultured overnight with and without phorbol 12-myristate 13-acetate/ionomycin. Cytokines and chemokines were measured in serum and cell supernatants, and mRNA expression was assessed by using quantitative real-time PCR. Results: Eight of the 210 subjects referred for the evaluation of eosinophilia (absolute eosinophil count [AEC] > 1500/µL) met the criteria for HEUS of 5 years duration or more (range, 7?29 years). Peak eosinophil count and surface expression of eosinophil activation markers were similar in subjects with HEUS and in untreated subjects with platelet-derived growth factor alpha?negative HES (n = 28). Aberrant or clonal T-cell populations were identified in 50% of the subjects with HEUS as compared to 29% of the subjects with HES (P = .12). Increased levels of IL-5, GM-CSF, IL-9, and IL-17A were also comparable in subjects with HEUS and HES. Serum levels of IgE and IL-13 were significantly increased only in subjects with HES. Conclusions: A small number of patients with persistent peripheral eosinophilia (AEC > 1500/µL) appear to have clinically benign disease. Twit Text FOAVip Marked and persistent eosinophilia in the absence of clinical manifestations ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23987798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23987798 #FOAvip English Wikipedia <ref>{{Cite pmid|23987798}}</ref> Marked and persistent eosinophilia in the absence of clinical manifestations #MMPMID23987798 Chen YYK; Khoury P; Ware JM; Holland-Thomas NC; Stoddard JL; Gurprasad S; Waldner AJ; Klion AD J Allergy Clin Immunol 2014[Apr]; 133 (4): 1195-1202.e2 PMID23987798show ga Background: Although most patients with hypereosinophilic syndromes (HES) present with clinical signs and symptoms attributable to eosinophilic tissue infiltration, some untreated patients remain asymptomatic or have signs and symptoms, such as allergic rhinitis, for which the relationship to peripheral eosinophilia is unclear (hypereosinophilia of unknown significance [HEUS]). Objective: To identify and characterize subjects with HEUS of 5 years duration or more as compared to untreated patients with symptomatic HES and healthy normal volunteers. Methods: All subjects with eosinophilia underwent yearly evaluation, including a standardized clinical evaluation, whole blood flow cytometry to assess lymphocyte subsets and eosinophil activation, and serum collection. Peripheral blood mononuclear cells were cultured overnight with and without phorbol 12-myristate 13-acetate/ionomycin. Cytokines and chemokines were measured in serum and cell supernatants, and mRNA expression was assessed by using quantitative real-time PCR. Results: Eight of the 210 subjects referred for the evaluation of eosinophilia (absolute eosinophil count [AEC] > 1500/µL) met the criteria for HEUS of 5 years duration or more (range, 7?29 years). Peak eosinophil count and surface expression of eosinophil activation markers were similar in subjects with HEUS and in untreated subjects with platelet-derived growth factor alpha?negative HES (n = 28). Aberrant or clonal T-cell populations were identified in 50% of the subjects with HEUS as compared to 29% of the subjects with HES (P = .12). Increased levels of IL-5, GM-CSF, IL-9, and IL-17A were also comparable in subjects with HEUS and HES. Serum levels of IgE and IL-13 were significantly increased only in subjects with HES. Conclusions: A small number of patients with persistent peripheral eosinophilia (AEC > 1500/µL) appear to have clinically benign disease. äMarked and persistent eosinophilia in the absence of clinical manifest(epmc).pdf DeepDyve Pubget Overpricing