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10.1093/infdis/jit527 http://scihub22266oqcxt.onion/10.1093/infdis/jit527 C3935471!3935471 !24072844     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24072844 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Infect+Dis 2014 ; 209 (6 ): 865-75 Nephropedia Template TP {{tp|p=24072844 |t=2014. Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production |pdf=|usr=}}{{24072844 }} gab.com Text Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24072844 #FOAvip Influenza A represents a significant cause of morbidity and mortality worldwide. Bacterial complications of influenza A confer the greatest risk to patients. TH17 pathway inhibition has been implicated as a mechanism by which influenza A alters bacterial host defense. Here we show that preceding influenza causes persistent Staphylococcus aureus infection and suppression of TH17 pathway activation in mice. Influenza does not inhibit S. aureus binding and uptake by phagocytic cells but instead attenuates S. aureus induced TH17 related antimicrobial peptides necessary for bacterial clearance in the lung. Importantly, exogenous lipocalin 2 rescued viral exacerbation of S. aureus infection and decreased free iron levels in the bronchoalveolar lavage from mice coinfected with S. aureus and influenza. These findings indicate a novel mechanism by which influenza A inhibits TH17 immunity and increases susceptibility to secondary bacterial pneumonia. Identification of new mechanisms in the pathogenesis of bacterial pneumonia could lead to future therapeutic targets. Twit Text FOAVip Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=24072844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24072844 #FOAvip English Wikipedia <ref>{{Cite pmid|24072844 }}</ref> Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production #MMPMID24072844 Robinson KM ; McHugh KJ ; Mandalapu S ; Clay ME ; Lee B ; Scheller EV ; Enelow RI ; Chan YR ; Kolls JK ; Alcorn JF J Infect Dis 2014[Mar]; 209 (6 ): 865-75 PMID24072844 show ga Influenza A represents a significant cause of morbidity and mortality worldwide. Bacterial complications of influenza A confer the greatest risk to patients. TH17 pathway inhibition has been implicated as a mechanism by which influenza A alters bacterial host defense. Here we show that preceding influenza causes persistent Staphylococcus aureus infection and suppression of TH17 pathway activation in mice. Influenza does not inhibit S. aureus binding and uptake by phagocytic cells but instead attenuates S. aureus induced TH17 related antimicrobial peptides necessary for bacterial clearance in the lung. Importantly, exogenous lipocalin 2 rescued viral exacerbation of S. aureus infection and decreased free iron levels in the bronchoalveolar lavage from mice coinfected with S. aureus and influenza. These findings indicate a novel mechanism by which influenza A inhibits TH17 immunity and increases susceptibility to secondary bacterial pneumonia. Identification of new mechanisms in the pathogenesis of bacterial pneumonia could lead to future therapeutic targets. |Analysis of Variance [MESH] |Animals [MESH] |Antimicrobial Cationic Peptides/*metabolism [MESH] |Bronchoalveolar Lavage Fluid/chemistry/microbiology/virology [MESH] |Coinfection/microbiology/virology [MESH] |Host-Pathogen Interactions/immunology [MESH] |Influenza A virus/*immunology/pathogenicity [MESH] |Macrophages/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neutrophils/immunology [MESH] |Orthomyxoviridae Infections/immunology/*microbiology/virology [MESH] |Pneumonia, Staphylococcal/immunology/*microbiology/virology [MESH] |Staphylococcus aureus/*immunology/pathogenicity [MESH]Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice (epmc).pdf DeepDyve Pubget Overpricing