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10.1111/j.1582-4934.2006.tb00408.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2006.tb00408.x C3933130!3933130!16796808     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2006 ; 10 (2): 407-22 Nephropedia Template TP {{tp|p=16796808|t=2006. Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose |pdf=|usr=}}{{16796808}} gab.com Text Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=16796808 #FOAvip Cyclic ADP-ribose (cADPR) is a novel Ca2+ mobilizing second messenger, which is capable of inducing Ca2+ release from the sarcoplasmic reticulum (SR) via activation of ryanodine receptors (RyR) in vascular cells. This signaling nucleotide has also been reported to participate in generation or modulation of intracellular Ca2+ sparks 2+waves or oscillations, Ca2+-induced Ca2+ release (CICR) and spontaneous transient outward currents (STOCs) in vascular smooth muscle cells (VSMCs). With respect to the role of cADPR-mediated signaling in mediation of vascular responses to different stimuli, there is accumulating evidence showing that cADPR is importantly involved in the Ca2+ response of vascular endothelial cells (ECs) and VSMCs to various chemical factors such as vasoactive agonists acetylcholine, oxotemorine, endothelin, and physical stimuli such as stretch, electrical depolarization and sheer stress. This cADPR-RyR-mediated Ca2+ signaling is now recognized as a fundamental mechanism regulating vascular function. Here we reviewed the literature regarding this cADPR signaling pathway in vascular cells with a major focus on the production of cADPR and its physiological roles in the control of vascular tone and vasomotor response. We also summarized some publish results that unveil the underlying mechanisms mediating the actions of cADPR in vascular cells. Given the importance of Ca2+ in the regulation of vascular function, the results summarized in this brief review will provide new insights into vascular physiology and circulatory regulation. Twit Text FOAVip Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=16796808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16796808 #FOAvip English Wikipedia <ref>{{Cite pmid|16796808}}</ref> Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP - ribose #MMPMID16796808 Zhang AY; Li P- L J Cell Mol Med 2006[Apr]; 10 (2): 407-22 PMID16796808show ga Cyclic ADP-ribose (cADPR) is a novel Ca2+ mobilizing second messenger, which is capable of inducing Ca2+ release from the sarcoplasmic reticulum (SR) via activation of ryanodine receptors (RyR) in vascular cells. This signaling nucleotide has also been reported to participate in generation or modulation of intracellular Ca2+ sparks 2+waves or oscillations, Ca2+-induced Ca2+ release (CICR) and spontaneous transient outward currents (STOCs) in vascular smooth muscle cells (VSMCs). With respect to the role of cADPR-mediated signaling in mediation of vascular responses to different stimuli, there is accumulating evidence showing that cADPR is importantly involved in the Ca2+ response of vascular endothelial cells (ECs) and VSMCs to various chemical factors such as vasoactive agonists acetylcholine, oxotemorine, endothelin, and physical stimuli such as stretch, electrical depolarization and sheer stress. This cADPR-RyR-mediated Ca2+ signaling is now recognized as a fundamental mechanism regulating vascular function. Here we reviewed the literature regarding this cADPR signaling pathway in vascular cells with a major focus on the production of cADPR and its physiological roles in the control of vascular tone and vasomotor response. We also summarized some publish results that unveil the underlying mechanisms mediating the actions of cADPR in vascular cells. Given the importance of Ca2+ in the regulation of vascular function, the results summarized in this brief review will provide new insights into vascular physiology and circulatory regulation. äVascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP(epmc).pdf DeepDyve Pubget Overpricing