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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Immunol 2014 ; 44 (2): 397-408 Nephropedia Template TP
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Both infection with Pneumocystis and virus-like particle exposure prime pulmonary CD11c+ cells, facilitating accelerated immune responses to influenza #MMPMID24222381
Richert LE; Rynda-Apple A; Harmsen AL; Han S; Wiley JA; Douglas T; Larson K; Morton RV; Harmsen AG
Eur J Immunol 2014[Feb]; 44 (2): 397-408 PMID24222381show ga
We show that the intranasal delivery of non-replicative virus-like particles (VLPs), which bear structural, but no antigenic similarities to respiratory pathogens, acted to prime the lungs of mice to facilitate heightened and accelerated primary immune responses to high-dose influenza challenge, thus providing a non-pathogenic model of innate imprinting. These responses corresponded closely to those observed following natural infection with the opportunistic fungus, Pneumocystis murina, and were characterized by accelerated antigen processing by dendritic cells (DCs) and alveolar macrophages (AMs), an enhanced influx of cells to the local tracheobronchial lymph node (TBLN), and early upregulation of T cell co-stimulatory/adhesion molecules. CD11c+ cells (DCs and AMs) which had been directly exposed to VLPs or Pneumocystis were necessary in facilitating the observed enhanced clearance of influenza virus. Furthermore, the repopulation of the lung by Ly-6C+ myeloid precursors relied on the expression of CCR2, and in the absence of efficient CCR2-mediated trafficking, resistance to influenza afforded by VLP- or Pneumocystis-exposure was lost. Thus, immune imprinting 72 hours after VLP-, or 2 weeks after Pneumocystis-priming was CCR2-mediated and resulted from the enhanced antigen processing, maturation, and trafficking abilities of DCs and AMs, which caused accelerated influenza-specific primary immune responses, and resulted in superior viral clearance.