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10.1111/j.1582-4934.2010.01024.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2010.01024.x C3922381!3922381!20132412     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20132412&cmd=llinks): Failed to open stream: HTTP request failed! 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Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells |pdf=|usr=}}{{20132412}} gab.com Text Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=20132412 #FOAvip Depression is associated with vascular disease, such as myocardial infarction and stroke. Pharmacological treatments may contribute to this association. On the other hand, Mg2+ deficiency is also known to be a risk factor for the same category of diseases. In the present study, we examined the effect of imipramine on Mg2+ homeostasis in vascular smooth muscle, especially via melastatin-type transient receptor potential (TRPM)-like Mg2+-permeable channels. The intracellular free Mg2+ concentration ([Mg2+]i) was measured using 31P-nuclear magnetic resonance (NMR) in porcine carotid arteries that express both TRPM6 and TRPM7, the latter being predominant. pHi and intracellular phosphorus compounds were simultaneously monitored. To rule out Na+-dependent Mg2+ transport, and to facilitate the activity of Mg2+-permeable channels, experiments were carried out in the absence of Na+ and Ca2+. Changing the extracellular Mg2+ concentration to 0 and 6 mM significantly decreased and increased [Mg2+]i, respectively, in a time-dependent manner. Imipramine statistically significantly attenuated both of the bi-directional [Mg2+]i changes under the Na+- and Ca2+-free conditions. This inhibitory effect was comparable in influx, and much more potent in efflux to that of 2-aminoethoxydiphenyl borate, a well-known blocker of TRPM7, a channel that plays a major role in cellular Mg2+ homeostasis. Neither [ATP]i nor pHi correlated with changes in [Mg2+]i. The results indicate that imipramine suppresses Mg2+-permeable channels presumably through a direct effect on the channel domain. This inhibitory effect appears to contribute, at least partially, to the link between antidepressants and the risk of vascular diseases. Twit Text FOAVip Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=20132412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20132412 #FOAvip English Wikipedia <ref>{{Cite pmid|20132412}}</ref> Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells #MMPMID20132412 Hamaguchi Y; Tatematsu Y; Furukawa K; Matsubara T; Nakayama S J Cell Mol Med 2011[Mar]; 15 (3): 593-601 PMID20132412show ga Depression is associated with vascular disease, such as myocardial infarction and stroke. Pharmacological treatments may contribute to this association. On the other hand, Mg2+ deficiency is also known to be a risk factor for the same category of diseases. In the present study, we examined the effect of imipramine on Mg2+ homeostasis in vascular smooth muscle, especially via melastatin-type transient receptor potential (TRPM)-like Mg2+-permeable channels. The intracellular free Mg2+ concentration ([Mg2+]i) was measured using 31P-nuclear magnetic resonance (NMR) in porcine carotid arteries that express both TRPM6 and TRPM7, the latter being predominant. pHi and intracellular phosphorus compounds were simultaneously monitored. To rule out Na+-dependent Mg2+ transport, and to facilitate the activity of Mg2+-permeable channels, experiments were carried out in the absence of Na+ and Ca2+. Changing the extracellular Mg2+ concentration to 0 and 6 mM significantly decreased and increased [Mg2+]i, respectively, in a time-dependent manner. Imipramine statistically significantly attenuated both of the bi-directional [Mg2+]i changes under the Na+- and Ca2+-free conditions. This inhibitory effect was comparable in influx, and much more potent in efflux to that of 2-aminoethoxydiphenyl borate, a well-known blocker of TRPM7, a channel that plays a major role in cellular Mg2+ homeostasis. Neither [ATP]i nor pHi correlated with changes in [Mg2+]i. The results indicate that imipramine suppresses Mg2+-permeable channels presumably through a direct effect on the channel domain. This inhibitory effect appears to contribute, at least partially, to the link between antidepressants and the risk of vascular diseases. äImipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vasc(epmc).pdf DeepDyve Pubget Overpricing