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10.1016/j.gde.2013.05.007 http://scihub22266oqcxt.onion/10.1016/j.gde.2013.05.007 C3915057!3915057!23790415     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Genet+Dev 2013 ; 23 (3): 271-9 Nephropedia Template TP {{tp|p=23790415|t=2013. Break-induced replication: functions and molecular mechanism |pdf=|usr=}}{{23790415}} gab.com Text Break-induced replication: functions and molecular mechanism JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=23790415 #FOAvip Break-induced replication (BIR) is the pathway of homologous recombination (HR) conserved from phages to eukaryotes that serves to repair DNA breaks that have only one end. BIR contributes to the repair of broken replication forks and allows telomere lengthening in the absence of telomerase. Nonallelic BIR may lead to translocations and other chromosomal rearrangements. In addition, BIR initiated at sites of microhomology can generate copy-number variations and complex chromosomal changes. The level of mutagenesis associated with DNA synthesis in BIR is significantly higher than during normal replication. These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution. Twit Text FOAVip Break-induced replication: functions and molecular mechanism ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=23790415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23790415 #FOAvip English Wikipedia <ref>{{Cite pmid|23790415}}</ref> Break-induced replication: functions and molecular mechanism #MMPMID23790415 Malkova A; Ira G Curr Opin Genet Dev 2013[Jun]; 23 (3): 271-9 PMID23790415show ga Break-induced replication (BIR) is the pathway of homologous recombination (HR) conserved from phages to eukaryotes that serves to repair DNA breaks that have only one end. BIR contributes to the repair of broken replication forks and allows telomere lengthening in the absence of telomerase. Nonallelic BIR may lead to translocations and other chromosomal rearrangements. In addition, BIR initiated at sites of microhomology can generate copy-number variations and complex chromosomal changes. The level of mutagenesis associated with DNA synthesis in BIR is significantly higher than during normal replication. These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution. äBreak-induced replication: functions and molecular mechanism (epmc).pdf DeepDyve Pubget Overpricing