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10.1007/s10059-013-0091-0 http://scihub22266oqcxt.onion/10.1007/s10059-013-0091-0 C3887975!3887975 !23912597     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23912597 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cells 2013 ; 36 (3 ): 235-44 Nephropedia Template TP {{tp|p=23912597 |t=2013. Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine |pdf=|usr=}}{{23912597 }} gab.com Text Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=23912597 #FOAvip Interstitial cells of Cajal (ICCs) are the pacemakers of the gastrointestinal tract, and transient receptor potential melastatin type 7 (TRPM7) and Ca(2+) activated Cl(-) channels (ANO1) are candidate the generators of pacemaker potentials in ICCs. The effects of D-erythro-sphingosine (SPH) and structural analogues of SPH, that is, N,N-dimethyl-Derythro-sphingosine (N,N-DMS), FTY720, and FTY720-P on the pacemaking activities of ICCs were examined using the whole cell patch clamp technique. SPH, N,N-DMS, and FTY720 decreased the amplitudes of pacemaker potentials in ICC clusters, but resting membrane potentials displayed little change. Also, perfusing SPH, N,N-DMS, or FTY720 in the bath reduced both inward and outward TRPM7-like currents in single ICCs, and inhibited ANO1 currents. The another structural analogue of SPH, FTY720-P was ineffective at the pacemaker potentials in ICC clusters and the TRPM7-like currents in single ICCs. Furthermore, FTY720-P had no effect on ANO1. These results suggest that SPH, N,N-DMS, and FTY720 modulate the pacemaker activities of ICCs, and that TRPM7 and ANO1 channels affect intestinal motility. Twit Text FOAVip Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=23912597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23912597 #FOAvip English Wikipedia <ref>{{Cite pmid|23912597 }}</ref> Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine #MMPMID23912597 Nam JH ; Kim WK ; Kim BJ Mol Cells 2013[Sep]; 36 (3 ): 235-44 PMID23912597 show ga Interstitial cells of Cajal (ICCs) are the pacemakers of the gastrointestinal tract, and transient receptor potential melastatin type 7 (TRPM7) and Ca(2+) activated Cl(-) channels (ANO1) are candidate the generators of pacemaker potentials in ICCs. The effects of D-erythro-sphingosine (SPH) and structural analogues of SPH, that is, N,N-dimethyl-Derythro-sphingosine (N,N-DMS), FTY720, and FTY720-P on the pacemaking activities of ICCs were examined using the whole cell patch clamp technique. SPH, N,N-DMS, and FTY720 decreased the amplitudes of pacemaker potentials in ICC clusters, but resting membrane potentials displayed little change. Also, perfusing SPH, N,N-DMS, or FTY720 in the bath reduced both inward and outward TRPM7-like currents in single ICCs, and inhibited ANO1 currents. The another structural analogue of SPH, FTY720-P was ineffective at the pacemaker potentials in ICC clusters and the TRPM7-like currents in single ICCs. Furthermore, FTY720-P had no effect on ANO1. These results suggest that SPH, N,N-DMS, and FTY720 modulate the pacemaker activities of ICCs, and that TRPM7 and ANO1 channels affect intestinal motility. |Animals [MESH] |Biological Clocks [MESH] |Chloride Channels/*physiology [MESH] |Female [MESH] |Fingolimod Hydrochloride [MESH] |Gastrointestinal Motility/*physiology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Interstitial Cells of Cajal/drug effects/*physiology [MESH] |Intestine, Small/*physiology [MESH] |Male [MESH] |Membrane Potentials [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Organophosphates/pharmacology [MESH] |Patch-Clamp Techniques [MESH] |Propylene Glycols/pharmacology [MESH] |Sphingosine/*analogs & derivatives/*pharmacology [MESH]Sphingosine and FTY720 modulate pacemaking activity in interstitial ce(epmc).pdf DeepDyve Pubget Overpricing