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2011 ; 32
(2
): 153-60
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Effects of transient receptor potential channel blockers on pacemaker activity in
interstitial cells of Cajal from mouse small intestine
#MMPMID21607648
Kim BJ
; Nam JH
; Kim SJ
Mol Cells
2011[Aug]; 32
(2
): 153-60
PMID21607648
show ga
The interstitial cells of Cajal (ICCs) are pacemakers in the gastrointestinal
tract and transient receptor potential melastatin type 7 (TRPM7) is a candidate
for pacemaker channels. The effect of the 5-lipoxygenase (5-LOX) inhibitors NDGA,
AA861, MK886 and zileuton on pacemaking activity of ICCs was examined using the
whole cell patch clamp technique. NDGA and AA861 decreased the amplitude of
pacemaker potentials in ICC clusters, but the resting membrane potentials
displayed little change, respectively. Also, perfusing NDGA and AA861 into the
bath reduced both inward current and outward current in TRPM7-like current in
single ICC, respectively. But, they had no effects on Ca(2+) activated Cl(-)
currents. The 5-LOX inhibitors MK886 and zileuton were, however, ineffective in
pacemaker potentials in ICC clusters and in TRPM7-like current in single ICC,
respectively. A specific TRPC3 inhibitor, pyrazole compound (Pyr3), and a
specific TRPM4 inhibitor, 9-phenanthrol, had no effects in pacemaker potentials
in ICC clusters and in TRPM7-like current in single ICC. These results suggest
that, among the tested 5-LOX inhibitors, NDGA and AA861 modulate the pacemaker
activities of the ICCs, and that the TRPM7 channel can affect intestinal
motility.
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