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10.1155/2013/342686

http://scihub22266oqcxt.onion/10.1155/2013/342686
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C3886489!3886489!24454472
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suck abstract from ncbi


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pmid24454472      Clin+Dev+Immunol 2013 ; 2013 (ä): ä
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  • Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain #MMPMID24454472
  • Potapova OV; Sharkova TV; Shkurupiy VA; Shestopalov AM
  • Clin Dev Immunol 2013[]; 2013 (ä): ä PMID24454472show ga
  • Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-?, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.
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