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10.4049/jimmunol.1101765 http://scihub22266oqcxt.onion/10.4049/jimmunol.1101765 C3884513!3884513!22611240     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2012 ; 188 (12): ä Nephropedia Template TP {{tp|p=22611240|t=2012. Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism |pdf=|usr=}}{{22611240}} gab.com Text Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22611240 #FOAvip MgSO4 exposure before preterm birth is neuroprotective, reducing the risk of cerebral palsy and major motor dysfunction. Neonatal inflammatory cytokine levels correlate with neurologic outcome, leading us to assess the effect of MgSO4 on cytokine production in humans. We found reduced maternal TNF-? and IL-6 production following in vivo MgSO4 treatment. Short-term exposure to a clinically effective MgSO4 concentration in vitro substantially reduced the frequency of neonatal monocytes producing TNF-? and IL-6 under constitutive and TLR-stimulated conditions, decreasing cytokine gene and protein expression, without influencing cell viability or phagocytic function. In summary, MgSO4 reduced cytokine production in intrapartum women, term and preterm neonates, demonstrating effectiveness in those at risk for inflammation-associated adverse perinatal outcomes. By probing the mechanism of decreased cytokine production, we found that the immunomodulatory effect was mediated by magnesium and not the sulfate moiety, and it was reversible. Cellular magnesium content increased rapidly upon MgSO4 exposure, and reduced cytokine production occurred following stimulation with different TLR ligands as well as when magnesium was added after TLR stimulation, strongly suggesting that magnesium acts intracellularly. Magnesium increased basal I?B? levels, and upon TLR stimulation was associated with reduced NF-?B activation and nuclear localization. These findings establish a new paradigm for innate immunoregulation, whereby magnesium plays a critical regulatory role in NF-?B activation, cytokine production, and disease pathogenesis. Twit Text FOAVip Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22611240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22611240 #FOAvip English Wikipedia <ref>{{Cite pmid|22611240}}</ref> Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism #MMPMID22611240 Sugimoto J; Romani AM; Valentin-Torres AM; Luciano AA; Ramirez Kitchen CM; Funderburg N; Mesiano S; Bernstein HB J Immunol 2012[Jun]; 188 (12): ä PMID22611240show ga MgSO4 exposure before preterm birth is neuroprotective, reducing the risk of cerebral palsy and major motor dysfunction. Neonatal inflammatory cytokine levels correlate with neurologic outcome, leading us to assess the effect of MgSO4 on cytokine production in humans. We found reduced maternal TNF-? and IL-6 production following in vivo MgSO4 treatment. Short-term exposure to a clinically effective MgSO4 concentration in vitro substantially reduced the frequency of neonatal monocytes producing TNF-? and IL-6 under constitutive and TLR-stimulated conditions, decreasing cytokine gene and protein expression, without influencing cell viability or phagocytic function. In summary, MgSO4 reduced cytokine production in intrapartum women, term and preterm neonates, demonstrating effectiveness in those at risk for inflammation-associated adverse perinatal outcomes. By probing the mechanism of decreased cytokine production, we found that the immunomodulatory effect was mediated by magnesium and not the sulfate moiety, and it was reversible. Cellular magnesium content increased rapidly upon MgSO4 exposure, and reduced cytokine production occurred following stimulation with different TLR ligands as well as when magnesium was added after TLR stimulation, strongly suggesting that magnesium acts intracellularly. Magnesium increased basal I?B? levels, and upon TLR stimulation was associated with reduced NF-?B activation and nuclear localization. These findings establish a new paradigm for innate immunoregulation, whereby magnesium plays a critical regulatory role in NF-?B activation, cytokine production, and disease pathogenesis. äMagnesium Decreases Inflammatory Cytokine Production: A Novel Innate I(epmc).pdf DeepDyve Pubget Overpricing