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10.1016/j.cgh.2013.06.013 http://scihub22266oqcxt.onion/10.1016/j.cgh.2013.06.013 C3883924!3883924!23811249     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Gastroenterol+Hepatol 2014 ; 12 (4): 555-64 Nephropedia Template TP {{tp|p=23811249|t=2014. Alcoholic Hepatitis: Current challenges and future directions |pdf=|usr=}}{{23811249}} gab.com Text Alcoholic Hepatitis: Current challenges and future directions JO: Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=23811249 #FOAvip Alcoholic hepatitis is a distinct clinical syndrome amongst people with chronic and active alcohol abuse with a potential for 30?40% mortality at one month amongst those with severe disease. Corticosteroids or pentoxifylline are the current pharmacological treatment options but provide only about 50% survival benefit. These agents are recommended for patients with modified discriminant function (mDF) of ?32 or model for end-stage disease (MELD) score of ?18. The Lille score is used to determine response to steroids. Currently, a minimum of 6 months abstinence from alcohol use is required for patients to receive a liver transplant, a requirement that cannot be met by patients with severe alcoholic hepatitis non-responsive to steroids (Lille score ?0.45). Data are emerging on the benefit of liver transplantation in select patients with first episode of severe alcoholic hepatitis. This review also focuses on recent treatment trials in alcoholic hepatitis including liver transplantation and its associated controversies, as well as possible future targets and pharmacological treatment options for patients with alcoholic hepatitis that are being pursued through upcoming consortium studies. Twit Text FOAVip Alcoholic Hepatitis: Current challenges and future directions ????Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=23811249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23811249 #FOAvip English Wikipedia <ref>{{Cite pmid|23811249}}</ref> Alcoholic Hepatitis: Current challenges and future directions #MMPMID23811249 Singal AK; Kamath PS; Gores GJ; Shah VH Clin Gastroenterol Hepatol 2014[Apr]; 12 (4): 555-64 PMID23811249show ga Alcoholic hepatitis is a distinct clinical syndrome amongst people with chronic and active alcohol abuse with a potential for 30?40% mortality at one month amongst those with severe disease. Corticosteroids or pentoxifylline are the current pharmacological treatment options but provide only about 50% survival benefit. These agents are recommended for patients with modified discriminant function (mDF) of ?32 or model for end-stage disease (MELD) score of ?18. The Lille score is used to determine response to steroids. Currently, a minimum of 6 months abstinence from alcohol use is required for patients to receive a liver transplant, a requirement that cannot be met by patients with severe alcoholic hepatitis non-responsive to steroids (Lille score ?0.45). Data are emerging on the benefit of liver transplantation in select patients with first episode of severe alcoholic hepatitis. This review also focuses on recent treatment trials in alcoholic hepatitis including liver transplantation and its associated controversies, as well as possible future targets and pharmacological treatment options for patients with alcoholic hepatitis that are being pursued through upcoming consortium studies. äAlcoholic Hepatitis: Current challenges and future directions (epmc).pdf DeepDyve Pubget Overpricing