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10.1097/01.aids.0000432450.37863.e9 http://scihub22266oqcxt.onion/10.1097/01.aids.0000432450.37863.e9 C3880635!3880635!23842125     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AIDS 2013 ; 27 (17): ä Nephropedia Template TP {{tp|p=23842125|t=2013. Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes |pdf=|usr=}}{{23842125}} gab.com Text Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes JO: AIDS http://www.kidney.de/pget.php?&tw=1&pmid=23842125 #FOAvip Objective: C. difficile is the most commonly reported infectious diarrhea in HIV-infected patients in the United States. We set out to determine the incidence, risk factors, and clinical presentation of C. difficile infections (CDI) in a cohort of HIV-infected subjects. Design: We performed a nested, case-control analysis with four non-CDI controls randomly selected for each case. Methods: We assessed the incidence of CDI in the Johns Hopkins HIV Clinical Cohort between July 1, 2003 and December 31, 2010. Incident cases were defined as first positive C. difficile cytotoxin assay or PCR for toxin B gene. We used conditional logistic regression models to assess risk factors for CDI. We abstracted data on the clinical presentation and outcomes from case chart review. Results: We identified 154 incident CDI cases for an incidence of 8.3 cases/1000 patient years. No unique clinical features of HIV-associated CDI were identified. In multivariate analysis, risk of CDI was independently increased for: CD4 count ?50 cells/mm3 (Adjusted Odds Ratio (AOR) 20.7, 95% CI 2.8?151.4), hospital onset CDI (AOR 26.7 [3.1?231.2]), and use of clindamycin (AOR 27.6 [2.2?339.4]), fluoroquinolones (AOR 4.5 [1.2?17.5]), macrolides (AOR 6.3 [1.8?22.1]), gastric acid suppressants (AOR 3.1 [1.4?6.9]), or immunosuppressive agents (AOR 6.8 [1.2?39.6]). Conclusions: The incidence of CDI in HIV-infected patients was twice that previously reported. Our data show compromised cellular immunity, as defined by CD4 ?50 cells/ mm3is a risk factor for CDI. Clinicians should be aware of the increased CDI risk, particularly in those with severe CD4 count suppression. Twit Text FOAVip Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes ????AIDS http://www.kidney.de/pget.php?&tw=1&pmid=23842125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23842125 #FOAvip English Wikipedia <ref>{{Cite pmid|23842125}}</ref> Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes #MMPMID23842125 Haines CF; Moore RD; Bartlett JG; Sears CL; Cosgrove SE; Carroll K; Gebo KA AIDS 2013[Nov]; 27 (17): ä PMID23842125show ga Objective: C. difficile is the most commonly reported infectious diarrhea in HIV-infected patients in the United States. We set out to determine the incidence, risk factors, and clinical presentation of C. difficile infections (CDI) in a cohort of HIV-infected subjects. Design: We performed a nested, case-control analysis with four non-CDI controls randomly selected for each case. Methods: We assessed the incidence of CDI in the Johns Hopkins HIV Clinical Cohort between July 1, 2003 and December 31, 2010. Incident cases were defined as first positive C. difficile cytotoxin assay or PCR for toxin B gene. We used conditional logistic regression models to assess risk factors for CDI. We abstracted data on the clinical presentation and outcomes from case chart review. Results: We identified 154 incident CDI cases for an incidence of 8.3 cases/1000 patient years. No unique clinical features of HIV-associated CDI were identified. In multivariate analysis, risk of CDI was independently increased for: CD4 count ?50 cells/mm3 (Adjusted Odds Ratio (AOR) 20.7, 95% CI 2.8?151.4), hospital onset CDI (AOR 26.7 [3.1?231.2]), and use of clindamycin (AOR 27.6 [2.2?339.4]), fluoroquinolones (AOR 4.5 [1.2?17.5]), macrolides (AOR 6.3 [1.8?22.1]), gastric acid suppressants (AOR 3.1 [1.4?6.9]), or immunosuppressive agents (AOR 6.8 [1.2?39.6]). Conclusions: The incidence of CDI in HIV-infected patients was twice that previously reported. Our data show compromised cellular immunity, as defined by CD4 ?50 cells/ mm3is a risk factor for CDI. Clinicians should be aware of the increased CDI risk, particularly in those with severe CD4 count suppression. äClostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factor(epmc).pdf DeepDyve Pubget Overpricing