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10.1083/jcb.201306054 http://scihub22266oqcxt.onion/10.1083/jcb.201306054 C3871439!3871439 !24344188     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24344188 &cmd=llinks): Failed to open stream: HTTP request failed! 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KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity |pdf=|usr=}}{{24344188 }} gab.com Text KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24344188 #FOAvip Aurora B kinase phosphorylates kinetochore proteins during early mitosis, increasing kinetochore?microtubule (MT) turnover and preventing premature stabilization of kinetochore?MT attachments. Phosphorylation of kinetochore proteins during late mitosis is low, promoting attachment stabilization, which is required for anaphase onset. The kinetochore protein KNL1 recruits Aurora B?counteracting phosphatases and the Aurora B?targeting factor Bub1, yet the consequences of KNL1 depletion on Aurora B phospho-regulation remain unknown. Here, we demonstrate that the KNL1 N terminus is essential for Aurora B activity at kinetochores. This region of KNL1 is also required for Bub1 kinase activity at kinetochores, suggesting that KNL1 promotes Aurora B activity through Bub1-mediated Aurora B targeting. However, ectopic targeting of Aurora B to kinetochores does not fully rescue Aurora B activity in KNL1-depleted cells, suggesting KNL1 influences Aurora B activity through an additional pathway. Our findings establish KNL1 as a requirement for Aurora B activity at kinetochores and for wild-type kinetochore?MT attachment dynamics. Twit Text FOAVip KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24344188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24344188 #FOAvip English Wikipedia <ref>{{Cite pmid|24344188 }}</ref> KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity #MMPMID24344188 Caldas GV ; DeLuca KF ; DeLuca JG J Cell Biol 2013[Dec]; 203 (6 ): 957-69 PMID24344188 show ga Aurora B kinase phosphorylates kinetochore proteins during early mitosis, increasing kinetochore?microtubule (MT) turnover and preventing premature stabilization of kinetochore?MT attachments. Phosphorylation of kinetochore proteins during late mitosis is low, promoting attachment stabilization, which is required for anaphase onset. The kinetochore protein KNL1 recruits Aurora B?counteracting phosphatases and the Aurora B?targeting factor Bub1, yet the consequences of KNL1 depletion on Aurora B phospho-regulation remain unknown. Here, we demonstrate that the KNL1 N terminus is essential for Aurora B activity at kinetochores. This region of KNL1 is also required for Bub1 kinase activity at kinetochores, suggesting that KNL1 promotes Aurora B activity through Bub1-mediated Aurora B targeting. However, ectopic targeting of Aurora B to kinetochores does not fully rescue Aurora B activity in KNL1-depleted cells, suggesting KNL1 influences Aurora B activity through an additional pathway. Our findings establish KNL1 as a requirement for Aurora B activity at kinetochores and for wild-type kinetochore?MT attachment dynamics. |Aurora Kinase B/metabolism/*physiology [MESH] |Cytoskeletal Proteins [MESH] |HeLa Cells [MESH] |Humans [MESH] |Kinetochores/*metabolism [MESH] |Microtubule-Associated Proteins/*physiology [MESH] |Microtubules/metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |Phosphorylation [MESH]KNL1 facilitates phosphorylation of outer kinetochore proteins by prom(epmc).pdf DeepDyve Pubget Overpricing