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In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as
assessed by optical coherence tomography
#MMPMID24302585
Wang B
; Nevins JE
; Nadler Z
; Wollstein G
; Ishikawa H
; Bilonick RA
; Kagemann L
; Sigal IA
; Grulkowski I
; Liu JJ
; Kraus M
; Lu CD
; Hornegger J
; Fujimoto JG
; Schuman JS
Invest Ophthalmol Vis Sci
2013[Dec]; 54
(13
): 8270-4
PMID24302585
show ga
PURPOSE: The lamina cribrosa (LC) is a prime location of glaucomatous damage. The
purpose of this study was to compare LC 3-dimensional micro-architecture between
healthy and glaucomatous eyes in vivo by using optical coherence tomography
(OCT). METHODS: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47
subjects were scanned in a 3.5 × 3.5 × 3.64-mm volume (400 × 400 × 896 pixels) at
the optic nerve head by using swept-source OCT. The LC micro-architecture
parameters were measured on the visible LC by an automated segmentation
algorithm. The LC parameters were compared to diagnosis and visual field mean
deviation (VF MD) by using a linear mixed effects model accounting for age.
RESULTS: The average VF MD for the healthy and glaucomatous eyes was -0.50 ± 0.80
dB and -7.84 ± 8.75 dB, respectively. Beam thickness to pore diameter ratio (P =
0.04) and pore diameter standard deviation (P < 0.01) were increased in
glaucomatous eyes. With worse MD, beam thickness to pore diameter ratio (P <
0.01), pore diameter standard deviation (P = 0.05), and beam thickness (P < 0.01)
showed a statistically significant increase while pore diameter (P = 0.02) showed
a significant decrease. There were no significant interactions between any of the
parameters and age (all P > 0.05). CONCLUSIONS: Glaucomatous micro-architecture
changes in the LC, detected by OCT analysis, reflect beams remodeling and axonal
loss leading to reduction in pore size and increased pore size variability.
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