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10.1523/JNEUROSCI.1592-13.2013 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.1592-13.2013 C3866416!3866416!24227727     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24227727.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neurosci 2013 ; 33 (46): 18190-9 Nephropedia Template TP {{tp|p=24227727|t=2013. Cerebral Arterial Pulsation Drives Paravascular CSF?Interstitial Fluid Exchange in the Murine Brain |pdf=|usr=}}{{24227727}} gab.com Text Cerebral Arterial Pulsation Drives Paravascular CSF Interstitial Fluid Exchange in the Murine Brain JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24227727 #FOAvip CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain interstitial fluid (ISF) and facilitating the clearance of interstitial solutes, such as amyloid ?, in a pathway that we have termed the ?glymphatic? system. Prior reports have suggested that paravascular bulk flow of CSF or ISF may be driven by arterial pulsation. However, cerebral arterial pulsation could not be directly assessed. In the present study, we use in vivo two-photon microscopy in mice to visualize vascular wall pulsatility in penetrating intracortical arteries. We observed that unilateral ligation of the internal carotid artery significantly reduced arterial pulsatility by ?50%, while systemic administration of the adrenergic agonist dobutamine increased pulsatility of penetrating arteries by ?60%. When paravascular CSF?ISF exchange was evaluated in real time using in vivo two-photon and ex vivo fluorescence imaging, we observed that internal carotid artery ligation slowed the rate of paravascular CSF?ISF exchange, while dobutamine increased the rate of paravascular CSF?ISF exchange. These findings demonstrate that cerebral arterial pulsatility is a key driver of paravascular CSF influx into and through the brain parenchyma, and suggest that changes in arterial pulsatility may contribute to accumulation and deposition of toxic solutes, including amyloid ?, in the aging brain. Twit Text FOAVip Cerebral Arterial Pulsation Drives Paravascular CSF Interstitial Fluid Exchange in the Murine Brain ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24227727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24227727 #FOAvip English Wikipedia <ref>{{Cite pmid|24227727}}</ref> Cerebral Arterial Pulsation Drives Paravascular CSF?Interstitial Fluid Exchange in the Murine Brain #MMPMID24227727 Iliff JJ; Wang M; Zeppenfeld DM; Venkataraman A; Plog BA; Liao Y; Deane R; Nedergaard M J Neurosci 2013[Nov]; 33 (46): 18190-9 PMID24227727show ga CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain interstitial fluid (ISF) and facilitating the clearance of interstitial solutes, such as amyloid ?, in a pathway that we have termed the ?glymphatic? system. Prior reports have suggested that paravascular bulk flow of CSF or ISF may be driven by arterial pulsation. However, cerebral arterial pulsation could not be directly assessed. In the present study, we use in vivo two-photon microscopy in mice to visualize vascular wall pulsatility in penetrating intracortical arteries. We observed that unilateral ligation of the internal carotid artery significantly reduced arterial pulsatility by ?50%, while systemic administration of the adrenergic agonist dobutamine increased pulsatility of penetrating arteries by ?60%. When paravascular CSF?ISF exchange was evaluated in real time using in vivo two-photon and ex vivo fluorescence imaging, we observed that internal carotid artery ligation slowed the rate of paravascular CSF?ISF exchange, while dobutamine increased the rate of paravascular CSF?ISF exchange. These findings demonstrate that cerebral arterial pulsatility is a key driver of paravascular CSF influx into and through the brain parenchyma, and suggest that changes in arterial pulsatility may contribute to accumulation and deposition of toxic solutes, including amyloid ?, in the aging brain. äCerebral Arterial Pulsation Drives Paravascular CSF?Interstitial Fluid(epmc).pdf DeepDyve Pubget Overpricing