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10.4049/jimmunol.1200571 http://scihub22266oqcxt.onion/10.4049/jimmunol.1200571 C3864858!3864858!23197262     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2013 ; 190 (1): ä Nephropedia Template TP {{tp|p=23197262|t=2013. Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection |pdf=|usr=}}{{23197262}} gab.com Text Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23197262 #FOAvip We have previously shown that mice challenged with a lethal dose of PR8-OVAI are protected by injection of 4 to 8 × 106in vitro - generated Tc1 or Tc17 CD8+ effectors. Viral load, lung damage and loss of lung function are all reduced following transfer. Weight loss is reduced and survival increased. We sought here to define the mechanism of this protection. CD8+ effectors exhibit multiple effector activities, perforin-, FasL- and TRAIL- mediated cytotoxicity, secretion of multiple cytokines (IL-2, IL-4, IL-5, IL-9, IL-10, IL-17, IL-21, IL-22, IFN-? and TNF) and chemokines (CCL3, CCL4, CCL5, CXCL9 and CXCL10). Transfer of CD8+ effectors into recipients, prior to infection, elicits enhanced recruitment of host neutrophils, NK cells, macrophages, and B cells. All of these events have the potential to protect against viral infections. Removal of any one, however, of these potential mechanisms was without effect on protection. Even the simultaneous removal of host T cells, host B cells and host neutrophils combined with the elimination of perforin mediated lytic mechanisms in the donor cells failed to reduce their ability to protect. We conclude that CD8+ effector T cells can protect against the lethal effects of viral infection by means of a large number of redundant mechanisms. Twit Text FOAVip Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23197262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23197262 #FOAvip English Wikipedia <ref>{{Cite pmid|23197262}}</ref> Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection #MMPMID23197262 Hamada H; Bassity E; Flies A; Strutt TM; Garcia-Hernandez Mde L; McKinstry KK; Zou T; Swain SL; Dutton RW J Immunol 2013[Jan]; 190 (1): ä PMID23197262show ga We have previously shown that mice challenged with a lethal dose of PR8-OVAI are protected by injection of 4 to 8 × 106in vitro - generated Tc1 or Tc17 CD8+ effectors. Viral load, lung damage and loss of lung function are all reduced following transfer. Weight loss is reduced and survival increased. We sought here to define the mechanism of this protection. CD8+ effectors exhibit multiple effector activities, perforin-, FasL- and TRAIL- mediated cytotoxicity, secretion of multiple cytokines (IL-2, IL-4, IL-5, IL-9, IL-10, IL-17, IL-21, IL-22, IFN-? and TNF) and chemokines (CCL3, CCL4, CCL5, CXCL9 and CXCL10). Transfer of CD8+ effectors into recipients, prior to infection, elicits enhanced recruitment of host neutrophils, NK cells, macrophages, and B cells. All of these events have the potential to protect against viral infections. Removal of any one, however, of these potential mechanisms was without effect on protection. Even the simultaneous removal of host T cells, host B cells and host neutrophils combined with the elimination of perforin mediated lytic mechanisms in the donor cells failed to reduce their ability to protect. We conclude that CD8+ effector T cells can protect against the lethal effects of viral infection by means of a large number of redundant mechanisms. äMultiple Redundant Effector Mechanisms of CD8+ T Cells Protect against(epmc).pdf DeepDyve Pubget Overpricing