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10.1083/jcb.201304143 http://scihub22266oqcxt.onion/10.1083/jcb.201304143 C3857477!3857477 !24322428     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24322428 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2013 ; 203 (5 ): 815-33 Nephropedia Template TP {{tp|p=24322428 |t=2013. FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions |pdf=|usr=}}{{24322428 }} gab.com Text FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24322428 #FOAvip By combining in vitro reconstitution biochemistry with a cross-linking approach, we have identified focal segmental glomerulosclerosis 3/CD2-associated protein (FSGS3/CD2AP) as a novel actin barbed-end capping protein responsible for actin stability at the adherens junction. FSGS3/CD2AP colocalizes with E-cadherin and ?-actinin-4 at the apical junction in polarized Madin-Darby canine kidney (MDCK) cells. Knockdown of FSGS3/CD2AP compromised actin stability and decreased actin accumulation at the adherens junction. Using a novel apparatus to apply mechanical stress to cell-cell junctions, we showed that knockdown of FSGS3/CD2AP compromised adhesive strength, resulting in tearing between cells and disruption of barrier function. Our results reveal a novel function of FSGS3/CD2AP and a previously unrecognized role of barbed-end capping in junctional actin dynamics. Our study underscores the complexity of actin regulation at cell-cell contacts that involves actin activators, inhibitors, and stabilizers to control adhesive strength, epithelial behavior, and permeability barrier integrity. Twit Text FOAVip FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=24322428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24322428 #FOAvip English Wikipedia <ref>{{Cite pmid|24322428 }}</ref> FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions #MMPMID24322428 Tang VW ; Brieher WM J Cell Biol 2013[Dec]; 203 (5 ): 815-33 PMID24322428 show ga By combining in vitro reconstitution biochemistry with a cross-linking approach, we have identified focal segmental glomerulosclerosis 3/CD2-associated protein (FSGS3/CD2AP) as a novel actin barbed-end capping protein responsible for actin stability at the adherens junction. FSGS3/CD2AP colocalizes with E-cadherin and ?-actinin-4 at the apical junction in polarized Madin-Darby canine kidney (MDCK) cells. Knockdown of FSGS3/CD2AP compromised actin stability and decreased actin accumulation at the adherens junction. Using a novel apparatus to apply mechanical stress to cell-cell junctions, we showed that knockdown of FSGS3/CD2AP compromised adhesive strength, resulting in tearing between cells and disruption of barrier function. Our results reveal a novel function of FSGS3/CD2AP and a previously unrecognized role of barbed-end capping in junctional actin dynamics. Our study underscores the complexity of actin regulation at cell-cell contacts that involves actin activators, inhibitors, and stabilizers to control adhesive strength, epithelial behavior, and permeability barrier integrity. |Actins/*metabolism [MESH] |Adaptor Proteins, Signal Transducing/analysis/chemistry/*physiology [MESH] |Adherens Junctions/*metabolism/ultrastructure [MESH] |Animals [MESH] |Cell Movement [MESH] |Cytoskeletal Proteins/analysis/chemistry/*physiology [MESH] |Dogs [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Madin Darby Canine Kidney Cells [MESH] |Polymerization [MESH]FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and (epmc).pdf DeepDyve Pubget Overpricing