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10.2174/1570159X11311060009 http://scihub22266oqcxt.onion/10.2174/1570159X11311060009 C3849791!3849791!24396341     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Neuropharmacol 2013 ; 11 (6): 664-76 Nephropedia Template TP {{tp|p=24396341|t=2013. Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives |pdf=|usr=}}{{24396341}} gab.com Text Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives JO: Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24396341 #FOAvip The efficacy of many of pain-relieving drugs is based on mechanisms by which the drugs interfere with the body?s natural pain-mediating pathways. By contrast, although it is less popular, other drugs including opioids exert more powerful analgesic actions by augmenting endogenous inhibitory neural circuits for pain mediation. Recently, a novel endogenous pain-inhibitory principle was suggested and is now attracting both scientific and clinical attentions. The central players for the actions are particular body lipids: resolvins. Although research is in the preclinical phase, multiple hypotheses have actively been matured regarding the potency and molecular and neural processes of the analgesic effects of these substances. Consistently, accumulating experimental evidence has been demonstrating that treatment with these lipid substances is strongly effective at controlling diverse types of pain. Treatment of resolvins does not appear to disturb the body homeostasis as severely as many other therapeutic agents that interrupt the body?s natural signaling flow, which enables us to predict their fewer adverse effects. This paper serves as a review of currently documented painkilling actions of resolvins, summarizes the potential cellular and receptor-mediated mechanisms to date, and discusses the many clinical uses for these therapeutic lipids that have not yet been tested. Future scientific efforts will more concentrate to unveil such aspects of the substances and to construct clear proofs of concept for pain relief. Twit Text FOAVip Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives ????Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24396341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24396341 #FOAvip English Wikipedia <ref>{{Cite pmid|24396341}}</ref> Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives #MMPMID24396341 Yoo S; Lim JY; Hwang SW Curr Neuropharmacol 2013[Dec]; 11 (6): 664-76 PMID24396341show ga The efficacy of many of pain-relieving drugs is based on mechanisms by which the drugs interfere with the body?s natural pain-mediating pathways. By contrast, although it is less popular, other drugs including opioids exert more powerful analgesic actions by augmenting endogenous inhibitory neural circuits for pain mediation. Recently, a novel endogenous pain-inhibitory principle was suggested and is now attracting both scientific and clinical attentions. The central players for the actions are particular body lipids: resolvins. Although research is in the preclinical phase, multiple hypotheses have actively been matured regarding the potency and molecular and neural processes of the analgesic effects of these substances. Consistently, accumulating experimental evidence has been demonstrating that treatment with these lipid substances is strongly effective at controlling diverse types of pain. Treatment of resolvins does not appear to disturb the body homeostasis as severely as many other therapeutic agents that interrupt the body?s natural signaling flow, which enables us to predict their fewer adverse effects. This paper serves as a review of currently documented painkilling actions of resolvins, summarizes the potential cellular and receptor-mediated mechanisms to date, and discusses the many clinical uses for these therapeutic lipids that have not yet been tested. Future scientific efforts will more concentrate to unveil such aspects of the substances and to construct clear proofs of concept for pain relief. äResolvins: Endogenously-Generated Potent Painkilling Substances and th(epmc).pdf DeepDyve Pubget Overpricing