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10.2174/1570159X113119990042 http://scihub22266oqcxt.onion/10.2174/1570159X113119990042 C3849788!3849788!24396338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Neuropharmacol 2013 ; 11 (6): 621-40 Nephropedia Template TP {{tp|p=24396338|t=2013. Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential |pdf=|usr=}}{{24396338}} gab.com Text Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential JO: Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24396338 #FOAvip Electrical excitation of peripheral somatosensory nerves is a first step in generation of most pain signals in mammalian nervous system. Such excitation is controlled by an intricate set of ion channels that are coordinated to produce a degree of excitation that is proportional to the strength of the external stimulation. However, in many disease states this coordination is disrupted resulting in deregulated peripheral excitability which, in turn, may underpin pathological pain states (i.e. migraine, neuralgia, neuropathic and inflammatory pains). One of the major groups of ion channels that are essential for controlling neuronal excitability is potassium channel family and, hereby, the focus of this review is on the K+ channels in peripheral pain pathways. The aim of the review is threefold. First, we will discuss current evidence for the expression and functional role of various K+ channels in peripheral nociceptive fibres. Second, we will consider a hypothesis suggesting that reduced functional activity of K+ channels within peripheral nociceptive pathways is a general feature of many types of pain. Third, we will evaluate the perspectives of pharmacological enhancement of K+ channels in nociceptive pathways as a strategy for new analgesic drug design. Twit Text FOAVip Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential ????Curr Neuropharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24396338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24396338 #FOAvip English Wikipedia <ref>{{Cite pmid|24396338}}</ref> Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential #MMPMID24396338 Du X; Gamper N Curr Neuropharmacol 2013[Dec]; 11 (6): 621-40 PMID24396338show ga Electrical excitation of peripheral somatosensory nerves is a first step in generation of most pain signals in mammalian nervous system. Such excitation is controlled by an intricate set of ion channels that are coordinated to produce a degree of excitation that is proportional to the strength of the external stimulation. However, in many disease states this coordination is disrupted resulting in deregulated peripheral excitability which, in turn, may underpin pathological pain states (i.e. migraine, neuralgia, neuropathic and inflammatory pains). One of the major groups of ion channels that are essential for controlling neuronal excitability is potassium channel family and, hereby, the focus of this review is on the K+ channels in peripheral pain pathways. The aim of the review is threefold. First, we will discuss current evidence for the expression and functional role of various K+ channels in peripheral nociceptive fibres. Second, we will consider a hypothesis suggesting that reduced functional activity of K+ channels within peripheral nociceptive pathways is a general feature of many types of pain. Third, we will evaluate the perspectives of pharmacological enhancement of K+ channels in nociceptive pathways as a strategy for new analgesic drug design. äPotassium Channels in Peripheral Pain Pathways: Expression, Function a(epmc).pdf DeepDyve Pubget Overpricing