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10.1161/ATVBAHA.113.301496 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.113.301496 C3844532!3844532 !23559629     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23559629 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arterioscler+Thromb+Vasc+Biol 2013 ; 33 (6 ): 1212-20 Nephropedia Template TP {{tp|p=23559629 |t=2013. mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells |pdf=|usr=}}{{23559629 }} gab.com Text mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23559629 #FOAvip OBJECTIVE: We studied the expression and function of an mRNA-binding protein, zinc finger protein-36 (ZFP36), in vascular endothelial cells in vivo and in vitro. We tested the hypotheses that ZFP36 regulates inflammation in vascular endothelial cells and that it functions through direct binding to target cytokine mRNAs. We also tested whether ZFP36 inhibits nuclear factor-?B-mediated transcriptional responses in vascular endothelial cells. APPROACH AND RESULTS: ZFP36 was minimally expressed in healthy aorta but was expressed in endothelial cells overlying atherosclerotic lesions in mice and humans. The protein was also expressed in macrophage foam cells of atherosclerosis. ZFP36 was expressed in human aortic endothelial cells in response to bacterial lipopolysaccharide, glucocorticoid, and forskolin, but not oxidized low-density lipoproteins or angiotensin II. Functional studies demonstrated that ZFP36 reduces the expression of inflammatory cytokines in target cells by 2 distinct mechanisms: ZFP36 inhibits nuclear factor-?B transcriptional activation and also binds to cytokine mRNAs, leading to reduced transcript stability. CONCLUSIONS: ZFP36 is expressed in vascular endothelial cells and macrophage foam cells where it inhibits the expression of proinflammatory mRNA transcripts. The anti-inflammatory effects of ZFP36 in endothelial cells occur via both transcriptional and posttranscriptional mechanisms. Our data suggest that enhancing vascular ZFP36 expression might reduce vascular inflammation. Twit Text FOAVip mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23559629 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23559629 #FOAvip English Wikipedia <ref>{{Cite pmid|23559629 }}</ref> mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells #MMPMID23559629 Zhang H ; Taylor WR ; Joseph G ; Caracciolo V ; Gonzales DM ; Sidell N ; Seli E ; Blackshear PJ ; Kallen CB Arterioscler Thromb Vasc Biol 2013[Jun]; 33 (6 ): 1212-20 PMID23559629 show ga OBJECTIVE: We studied the expression and function of an mRNA-binding protein, zinc finger protein-36 (ZFP36), in vascular endothelial cells in vivo and in vitro. We tested the hypotheses that ZFP36 regulates inflammation in vascular endothelial cells and that it functions through direct binding to target cytokine mRNAs. We also tested whether ZFP36 inhibits nuclear factor-?B-mediated transcriptional responses in vascular endothelial cells. APPROACH AND RESULTS: ZFP36 was minimally expressed in healthy aorta but was expressed in endothelial cells overlying atherosclerotic lesions in mice and humans. The protein was also expressed in macrophage foam cells of atherosclerosis. ZFP36 was expressed in human aortic endothelial cells in response to bacterial lipopolysaccharide, glucocorticoid, and forskolin, but not oxidized low-density lipoproteins or angiotensin II. Functional studies demonstrated that ZFP36 reduces the expression of inflammatory cytokines in target cells by 2 distinct mechanisms: ZFP36 inhibits nuclear factor-?B transcriptional activation and also binds to cytokine mRNAs, leading to reduced transcript stability. CONCLUSIONS: ZFP36 is expressed in vascular endothelial cells and macrophage foam cells where it inhibits the expression of proinflammatory mRNA transcripts. The anti-inflammatory effects of ZFP36 in endothelial cells occur via both transcriptional and posttranscriptional mechanisms. Our data suggest that enhancing vascular ZFP36 expression might reduce vascular inflammation. |*Gene Expression Regulation [MESH] |Animals [MESH] |Aorta [MESH] |Atherosclerosis/genetics/physiopathology [MESH] |Carrier Proteins/genetics/metabolism [MESH] |Cells, Cultured [MESH] |Cytokines/*metabolism [MESH] |Disease Models, Animal [MESH] |Endothelial Cells/cytology/*metabolism [MESH] |Foam Cells/cytology/*metabolism [MESH] |Humans [MESH] |Inflammation/genetics/prevention & control [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Random Allocation [MESH] |Reference Values [MESH] |Sensitivity and Specificity [MESH] |Tristetraprolin/*genetics [MESH]mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and(epmc).pdf DeepDyve Pubget Overpricing