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10.1016/j.neuroscience.2013.06.051 http://scihub22266oqcxt.onion/10.1016/j.neuroscience.2013.06.051 C3844067!3844067!23831425     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroscience 2014 ; ä (ä): 131-41 Nephropedia Template TP {{tp|p=23831425|t=2014. Chromatin-bound RNA and the Neurobiology of Psychiatric Disease |pdf=|usr=}}{{23831425}} gab.com Text Chromatin-bound RNA and the Neurobiology of Psychiatric Disease JO: Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=23831425 #FOAvip A large, and still rapidly expanding literature on epigenetic regulation in the nervous system has provided fundamental insights into the dynamic regulation of DNA methylation and post-translational histone modifications in the context of neuronal plasticity in health and disease. Remarkably, however, very little is known about the potential role of chromatin-bound RNAs, including many long non-coding transcripts and various types of small RNAs. Here, we provide an overview on RNA-mediated regulation of chromatin structure and function, with focus on histone lysine methylation and psychiatric disease. Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the Brain-derived Neurotrophic Factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels. We predict that the exploration of chromatin-bound RNA will significantly advance our current knowledge base in neuroepigenetics and biological psychiatry. Twit Text FOAVip Chromatin-bound RNA and the Neurobiology of Psychiatric Disease ????Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=23831425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23831425 #FOAvip English Wikipedia <ref>{{Cite pmid|23831425}}</ref> Chromatin-bound RNA and the Neurobiology of Psychiatric Disease #MMPMID23831425 Tushir JS; Akbarian S Neuroscience 2014[Apr]; ä (ä): 131-41 PMID23831425show ga A large, and still rapidly expanding literature on epigenetic regulation in the nervous system has provided fundamental insights into the dynamic regulation of DNA methylation and post-translational histone modifications in the context of neuronal plasticity in health and disease. Remarkably, however, very little is known about the potential role of chromatin-bound RNAs, including many long non-coding transcripts and various types of small RNAs. Here, we provide an overview on RNA-mediated regulation of chromatin structure and function, with focus on histone lysine methylation and psychiatric disease. Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the Brain-derived Neurotrophic Factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels. We predict that the exploration of chromatin-bound RNA will significantly advance our current knowledge base in neuroepigenetics and biological psychiatry. äChromatin-bound RNA and the Neurobiology of Psychiatric Disease (epmc).pdf DeepDyve Pubget Overpricing