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10.1007/s00467-013-2548-y http://scihub22266oqcxt.onion/10.1007/s00467-013-2548-y C3844055!3844055!23824180     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2014 ; 29 (4): 505-11 Nephropedia Template TP {{tp|p=23824180|t=2014. Polycystin-1 Cleavage and the Regulation of Transcriptional Pathways |pdf=|usr=}}{{23824180}} gab.com Text Polycystin-1 Cleavage and the Regulation of Transcriptional Pathways JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23824180 #FOAvip Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end stage renal disease, affecting ~1 in 1,000 people. The disease is characterized by the development of numerous large fluid filled renal cysts over the course of decades. These cysts compress the surrounding renal parenchyma and impair its function. Mutations in two genes are responsible for ADPKD. The protein products of both of these genes, polycystin-1 and polycystin-2, localize to the primary cilium and participate in a wide variety of signaling pathways. Polycystin-1 undergoes several proteolytic cleavages that produce fragments that manifest biological activities. Recent results suggest that the production of polycystin-1 cleavage fragments is necessary and sufficient to account for at least some, although certainly not all, of the physiological functions of the parent protein. Twit Text FOAVip Polycystin-1 Cleavage and the Regulation of Transcriptional Pathways ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23824180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23824180 #FOAvip English Wikipedia <ref>{{Cite pmid|23824180}}</ref> Polycystin-1 Cleavage and the Regulation of Transcriptional Pathways #MMPMID23824180 Merrick D; Bertuccio CA; Chapin HC; Lal M; Chauvet V; Caplan MJ Pediatr Nephrol 2014[Apr]; 29 (4): 505-11 PMID23824180show ga Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end stage renal disease, affecting ~1 in 1,000 people. The disease is characterized by the development of numerous large fluid filled renal cysts over the course of decades. These cysts compress the surrounding renal parenchyma and impair its function. Mutations in two genes are responsible for ADPKD. The protein products of both of these genes, polycystin-1 and polycystin-2, localize to the primary cilium and participate in a wide variety of signaling pathways. Polycystin-1 undergoes several proteolytic cleavages that produce fragments that manifest biological activities. Recent results suggest that the production of polycystin-1 cleavage fragments is necessary and sufficient to account for at least some, although certainly not all, of the physiological functions of the parent protein. äPolycystin-1 Cleavage and the Regulation of Transcriptional Pathways (epmc).pdf DeepDyve Pubget Overpricing