Central Role of RET in Thyroid Cancer #MMPMID24296167
Santoro M; Carlomagno F
Cold Spring Harb Perspect Biol 2013[Dec]; 5 (12): ä PMID24296167show ga
RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.