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10.1128/IAI.01026-13 http://scihub22266oqcxt.onion/10.1128/IAI.01026-13 C3837970!3837970 !24082072     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24082072 &cmd=llinks): Failed to open stream: HTTP request failed! 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Nlrp-3-driven interleukin 17 production by ??T cells controls infection outcomes during Staphylococcus aureus surgical site infection |pdf=|usr=}}{{24082072 }} gab.com Text Nlrp-3-driven interleukin 17 production by T cells controls infection outcomes during Staphylococcus aureus surgical site infection JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=24082072 #FOAvip Recent work has identified T cells and the cytokines they produce as important correlates of immune protection during Staphylococcus aureus infections through the ability of these T cells to regulate local neutrophil responses. However, the specific T-cell subsets that are involved in coordinating protection at distinct sites of infection remains to be established. In this study, we identify for the first time an important role for ??T cells in controlling S. aureus surgical site infection (SSI). ??T cells are recruited to the wound site following S. aureus challenge, where they represent the primary source of interleukin 17 (IL-17), with a small contribution from other non-??T cells. The IL-17 response is entirely dependent upon IL-1 receptor signaling. Using IL-17 receptor-deficient mice, we demonstrate that IL-17 is required to control bacterial clearance during S. aureus SSI. However, we demonstrate a strain-dependent requirement for ??T cells in this process due to the differential abilities of individual strains to activate IL-1? production. IL-1? processing relies upon activation of the Nlrp3 inflammasome complex, and we demonstrate that Nlrp3-deficient and IL-1 receptor-deficient mice have an impaired ability to control S. aureus SSI due to reduced production of IL-17 by ??T cells at the site of infection. Given that IL-17 has been identified as an important correlate of immune protection during S. aureus infection, it is vital that the unique cellular sources of this cytokine and mechanisms inducing its activation are identified at distinct sites of infection. Our study demonstrates that while IL-17 may be critically important for mediating immune protection during S. aureus SSI, the relative contribution of ??T cells to these protective effects may be strain dependent. Twit Text FOAVip Nlrp-3-driven interleukin 17 production by T cells controls infection outcomes during Staphylococcus aureus surgical site infection ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=24082072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24082072 #FOAvip English Wikipedia <ref>{{Cite pmid|24082072 }}</ref> Nlrp-3-driven interleukin 17 production by ??T cells controls infection outcomes during Staphylococcus aureus surgical site infection #MMPMID24082072 Maher BM ; Mulcahy ME ; Murphy AG ; Wilk M ; O'Keeffe KM ; Geoghegan JA ; Lavelle EC ; McLoughlin RM Infect Immun 2013[Dec]; 81 (12 ): 4478-89 PMID24082072 show ga Recent work has identified T cells and the cytokines they produce as important correlates of immune protection during Staphylococcus aureus infections through the ability of these T cells to regulate local neutrophil responses. However, the specific T-cell subsets that are involved in coordinating protection at distinct sites of infection remains to be established. In this study, we identify for the first time an important role for ??T cells in controlling S. aureus surgical site infection (SSI). ??T cells are recruited to the wound site following S. aureus challenge, where they represent the primary source of interleukin 17 (IL-17), with a small contribution from other non-??T cells. The IL-17 response is entirely dependent upon IL-1 receptor signaling. Using IL-17 receptor-deficient mice, we demonstrate that IL-17 is required to control bacterial clearance during S. aureus SSI. However, we demonstrate a strain-dependent requirement for ??T cells in this process due to the differential abilities of individual strains to activate IL-1? production. IL-1? processing relies upon activation of the Nlrp3 inflammasome complex, and we demonstrate that Nlrp3-deficient and IL-1 receptor-deficient mice have an impaired ability to control S. aureus SSI due to reduced production of IL-17 by ??T cells at the site of infection. Given that IL-17 has been identified as an important correlate of immune protection during S. aureus infection, it is vital that the unique cellular sources of this cytokine and mechanisms inducing its activation are identified at distinct sites of infection. Our study demonstrates that while IL-17 may be critically important for mediating immune protection during S. aureus SSI, the relative contribution of ??T cells to these protective effects may be strain dependent. |Animals [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Interleukin-17/biosynthesis/*immunology/metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Neutrophils/immunology [MESH] |Receptors, Antigen, T-Cell, gamma-delta/metabolism [MESH] |Receptors, Interleukin-1/deficiency/genetics [MESH] |Signal Transduction/immunology [MESH] |Staphylococcal Infections/*immunology [MESH] |Staphylococcus aureus/immunology [MESH] |Surgical Wound Infection/*immunology [MESH]Nlrp-3-driven interleukin 17 production by ??T cells controls infectio(epmc).pdf DeepDyve Pubget Overpricing