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10.1128/AAC.01444-13

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suck abstract from ncbi


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pmid24060878
      Antimicrob+Agents+Chemother 2013 ; 57 (12 ): 6372-7
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  • Whole-cell screening-based identification of inhibitors against the intraphagosomal survival of Mycobacterium tuberculosis #MMPMID24060878
  • Khare G ; Kumar P ; Tyagi AK
  • Antimicrob Agents Chemother 2013[Dec]; 57 (12 ): 6372-7 PMID24060878 show ga
  • We describe here an efficient strategy that employs whole-cell-based screening and further short listing of the compounds by cytotoxicity- and fluorescence-based intracellular assays, resulting in potential bactericidal hits against the growth of Mycobacterium tuberculosis in broth culture as well as in phagosomes. These compounds also inhibited multidrug-resistant strains of M. tuberculosis but showed no or poor inhibition of nonpathogenic mycobacteria or other bacterial species such as Escherichia coli.
  • |Anti-Bacterial Agents/*pharmacology [MESH]
  • |Escherichia coli/drug effects [MESH]
  • |Microbial Sensitivity Tests [MESH]
  • |Mycobacterium tuberculosis/drug effects [MESH]


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