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10.1016/j.ghir.2013.03.001 http://scihub22266oqcxt.onion/10.1016/j.ghir.2013.03.001 C3833084!3833084!23578754     free     free     free       Growth+Horm+IGF+Res 2013 ; 23 (3): ä Nephropedia Template TP {{tp|p=23578754|t=2013. An ocular view of the IGF-IGFBP system |pdf=|usr=}}{{23578754}} gab.com Text An ocular view of the IGF-IGFBP system JO: Growth Horm IGF Res http://www.kidney.de/pget.php?&tw=1&pmid=23578754 #FOAvip IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have characterized the expression patterns of different IGFBPs in retinal layers and within the vitreous. IGFBP-3 has roles in vascular protection stimulating proliferation, migration, and differentiation of vascular progenitor cells to sites of injury. IGFBP-3 increases pericyte ensheathment and shows anti-inflammatory effects by reducing microglia activation in diabetes. IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization. Thus, the regulatory balance between IGF and IGFBPs can have profound impact on target tissues. This review discusses recent findings of IGF and IGFBP expression in the eye with relevance to different retinopathies. Twit Text FOAVip An ocular view of the IGF-IGFBP system ????Growth Horm IGF Res http://www.kidney.de/pget.php?&tw=1&pmid=23578754 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23578754 #FOAvip English Wikipedia <ref>{{Cite pmid|23578754}}</ref> An ocular view of the IGF-IGFBP system #MMPMID23578754 Nguyen DV; Calzi SL; Shaw LC; Kielczewski JL; Korah HE; Grant MB Growth Horm IGF Res 2013[Jun]; 23 (3): ä PMID23578754show ga IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have characterized the expression patterns of different IGFBPs in retinal layers and within the vitreous. IGFBP-3 has roles in vascular protection stimulating proliferation, migration, and differentiation of vascular progenitor cells to sites of injury. IGFBP-3 increases pericyte ensheathment and shows anti-inflammatory effects by reducing microglia activation in diabetes. IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization. Thus, the regulatory balance between IGF and IGFBPs can have profound impact on target tissues. This review discusses recent findings of IGF and IGFBP expression in the eye with relevance to different retinopathies. äAn ocular view of the IGF-IGFBP system (epmc).pdf DeepDyve Pubget Overpricing