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10.1111/j.1582-4934.2007.00170.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2007.00170.x C3823473!3823473!18053092     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2008 ; 12 (1): 67-96 Nephropedia Template TP {{tp|p=18053092|t=2008. Cancer stem cells: the lessons from pre-cancerous stem cells |pdf=|usr=}}{{18053092}} gab.com Text Cancer stem cells: the lessons from pre-cancerous stem cells JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18053092 #FOAvip How a cancer is initiated and established remains elusive despite all the advances in decades of cancer research. Recently the cancer stem cell (CSC) hypothesis has been revived, challenging the long-standing model of ?clonal evolution? for cancer development and implicating the dawning of a potential cure for cancer [1]. The recent identification of pre-cancerous stem cells (pCSCs) in cancer, an early stage of CSC development, however, implicates that the clonal evolution is not contradictory to the CSC hypothesis but is rather an aspect of the process of CSC development [2]. The discovery of pCSC has revealed and will continue to reveal the volatile properties of CSC with respect to their phenotype, differentiation and tumourigenic capacity during initiation and progression. Both pCSC and CSC might also serve as precursors of tumour stromal components such as tumour vasculogenic stem/progenitor cells (TVPCs). Thus, the CSC hypothesis covers the developing process of tumour-initiating cells (TIC) ? pCSC ? CSC ? cancer, a cellular process that should parallel the histological process of hyperplasia/metaplasia (TIC) ? pre-cancerous lesions (pCSC) ? malignant lesions (CSC ? cancer). The embryonic stem (ES) cell and germ line stem (GS) cell genes are subverted in pCSCs. Especially the GS cell protein piwil2 may play an important role during the development of TIC ? pCSC ? CSC, and this protein may be used as a common biomarker for early detection, prevention, and treatment of cancer. As cancer stem cell research is yet in its infancy, definitive conclusions regarding the role of pCSC cannot be made at this time. However, this review will discuss what we have learned from pCSC and how this has led to innovative ideas that may eventually have major impacts on the understanding and treatment of cancer. Twit Text FOAVip Cancer stem cells: the lessons from pre-cancerous stem cells ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18053092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18053092 #FOAvip English Wikipedia <ref>{{Cite pmid|18053092}}</ref> Cancer stem cells: the lessons from pre-cancerous stem cells #MMPMID18053092 Gao JX J Cell Mol Med 2008[Jan]; 12 (1): 67-96 PMID18053092show ga How a cancer is initiated and established remains elusive despite all the advances in decades of cancer research. Recently the cancer stem cell (CSC) hypothesis has been revived, challenging the long-standing model of ?clonal evolution? for cancer development and implicating the dawning of a potential cure for cancer [1]. The recent identification of pre-cancerous stem cells (pCSCs) in cancer, an early stage of CSC development, however, implicates that the clonal evolution is not contradictory to the CSC hypothesis but is rather an aspect of the process of CSC development [2]. The discovery of pCSC has revealed and will continue to reveal the volatile properties of CSC with respect to their phenotype, differentiation and tumourigenic capacity during initiation and progression. Both pCSC and CSC might also serve as precursors of tumour stromal components such as tumour vasculogenic stem/progenitor cells (TVPCs). Thus, the CSC hypothesis covers the developing process of tumour-initiating cells (TIC) ? pCSC ? CSC ? cancer, a cellular process that should parallel the histological process of hyperplasia/metaplasia (TIC) ? pre-cancerous lesions (pCSC) ? malignant lesions (CSC ? cancer). The embryonic stem (ES) cell and germ line stem (GS) cell genes are subverted in pCSCs. Especially the GS cell protein piwil2 may play an important role during the development of TIC ? pCSC ? CSC, and this protein may be used as a common biomarker for early detection, prevention, and treatment of cancer. As cancer stem cell research is yet in its infancy, definitive conclusions regarding the role of pCSC cannot be made at this time. However, this review will discuss what we have learned from pCSC and how this has led to innovative ideas that may eventually have major impacts on the understanding and treatment of cancer. äCancer stem cells: the lessons from pre-cancerous stem cells (epmc).pdf DeepDyve Pubget Overpricing