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2010 ; 14
(4
): 729-40
Nephropedia Template TP
gab.com Text
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English Wikipedia
TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of
Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES
#MMPMID20367664
Popescu LM
; Faussone-Pellegrini MS
J Cell Mol Med
2010[Apr]; 14
(4
): 729-40
PMID20367664
show ga
Ramon y Cajal discovered a particular cell type in the gut, which he named
'interstitial neurons' more that 100 years ago. In the early 1970s, electron
microscopy/electron microscope (EM) studies showed that indeed a special
interstitial cell type corresponding to the cells discovered by Cajal is
localized in the gut muscle coat, but it became obvious that they were not
neurons. Consequently, they were renamed 'interstitial cells of Cajal' (ICC) and
considered to be pace-makers for gut motility. For the past 10 years many groups
were interested in whether or not ICC are present outside the gastrointestinal
tract, and indeed, peculiar interstitial cells were found in: upper and lower
urinary tracts, blood vessels, pancreas, male and female reproductive tracts,
mammary gland, placenta, and, recently, in the heart as well as in the gut. Such
cells, now mostly known as interstitial Cajal-like cells (ICLC), were given
different and confusing names. Moreover, ICLC are only apparently similar to
canonical ICC. In fact, EM and cell cultures revealed very particular features of
ICLC, which unequivocally distinguishes them from ICC and all other interstitial
cells: the presence of 2-5 cell body prolongations that are very thin (less than
0.2 mum, under resolving power of light microscopy), extremely long (tens to
hundreds of mum), with a moniliform aspect (many dilations along), as well as
caveolae. Given the unique dimensions of these prolongations (very long and very
thin) and to avoid further confusion with other interstitial cell types (e.g.
fibroblast, fibrocyte, fibroblast-like cells, mesenchymal cells), we are
proposing the term TELOCYTES for them, and TELOPODES for their prolongations, by
using the Greek affix 'telos'.
|*Terminology as Topic
[MESH]
|Animals
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Interstitial Cells of Cajal/*cytology/ultrastructure
[MESH]