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10.1111/j.1582-4934.2010.01089.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2010.01089.x C3822631!3822631!20477902     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2011 ; 15 (5): 1189-99 Nephropedia Template TP {{tp|p=20477902|t=2011. Identification of a novel antigen cross-presenting cell type in spleen |pdf=|usr=}}{{20477902}} gab.com Text Identification of a novel antigen cross-presenting cell type in spleen JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=20477902 #FOAvip Antigen-presenting cells (APC), like dendritic cells (DC), are essential for T-cell activation, leading to immunity or tolerance. Multiple DC subsets each play a unique role in the immune response. Here, a novel splenic dendritic-like APC has been characterized in mice that has immune function and cell surface phenotype distinct from other, described DC subsets. These were identified as a cell type continuously produced in spleen long-term cultures (LTC) and have an in vivo equivalent cell type in mice, namely ?L-DC?. This study characterizes LTC-DC in terms of marker phenotype and function, and compares them with L-DC and other known splenic DC and myeloid subsets. L-DC display a myeloid dendritic-like phenotype equivalent to LTC-DC as CD11cloCD11bhiMHC-II?CD8?? cells, distinct by high accessibility and endocytic capacity for blood-borne antigen. Both LTC-DC and L-DC have strong antigen cross-presentation ability leading to strong activation of CD8+ T cells, particularly after exposure to lipopolysaccharide. However, they have weak ability to stimulate CD4+ T cells in antigen-specific responses. Evidence is presented here for a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen. Twit Text FOAVip Identification of a novel antigen cross-presenting cell type in spleen ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=20477902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20477902 #FOAvip English Wikipedia <ref>{{Cite pmid|20477902}}</ref> Identification of a novel antigen cross-presenting cell type in spleen #MMPMID20477902 Tan JKH; Quah BJC; Griffiths KL; Periasamy P; Hey YY; O?Neill HC J Cell Mol Med 2011[May]; 15 (5): 1189-99 PMID20477902show ga Antigen-presenting cells (APC), like dendritic cells (DC), are essential for T-cell activation, leading to immunity or tolerance. Multiple DC subsets each play a unique role in the immune response. Here, a novel splenic dendritic-like APC has been characterized in mice that has immune function and cell surface phenotype distinct from other, described DC subsets. These were identified as a cell type continuously produced in spleen long-term cultures (LTC) and have an in vivo equivalent cell type in mice, namely ?L-DC?. This study characterizes LTC-DC in terms of marker phenotype and function, and compares them with L-DC and other known splenic DC and myeloid subsets. L-DC display a myeloid dendritic-like phenotype equivalent to LTC-DC as CD11cloCD11bhiMHC-II?CD8?? cells, distinct by high accessibility and endocytic capacity for blood-borne antigen. Both LTC-DC and L-DC have strong antigen cross-presentation ability leading to strong activation of CD8+ T cells, particularly after exposure to lipopolysaccharide. However, they have weak ability to stimulate CD4+ T cells in antigen-specific responses. Evidence is presented here for a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen. äIdentification of a novel antigen cross-presenting cell type in spleen(epmc).pdf DeepDyve Pubget Overpricing