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2012 ; 2012
(ä): 415158
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TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as
Cancer Biomarkers and Targets
#MMPMID24278689
Yee NS
; Chan AS
; Yee JD
; Yee RK
Scientifica (Cairo)
2012[]; 2012
(ä): 415158
PMID24278689
show ga
Transient receptor potential (TRP) ion channels are essential for normal
functions and health by acting as molecular sensors and transducing various
stimuli into cellular and physiological responses. Growing evidence has revealed
that TRP ion channels play important roles in a wide range of human diseases,
including malignancies. In light of recent discoveries, it has been found that
TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and
cancerous development of exocrine pancreas. We are currently investigating the
mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting
to develop these ion channels as clinical biomarkers and therapeutic targets for
achieving the goal of personalized therapy in pancreatic cancer.