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10.1111/imm.12110 http://scihub22266oqcxt.onion/10.1111/imm.12110 C3809700!3809700!23578170     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2013 ; 140 (1): 1-11 Nephropedia Template TP {{tp|p=23578170|t=2013. Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits |pdf=|usr=}}{{23578170}} gab.com Text Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=23578170 #FOAvip Anti-Gal is the most abundant natural antibody in humans, constituting ? 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the ??-gal epitope? with the structure Gal?1-3Gal?1-4GlcNAc-R. The ?-gal epitope is present as a major carbohydrate antigen in non-primate mammals, prosimians and New World monkeys. Anti-Gal can contributes to several immunological pathogeneses. Anti-Gal IgE produced in some individuals causes allergies to meat and to the therapeutic monoclonal antibody cetuximab, all presenting ?-gal epitopes. Aberrant expression of the ?-gal epitope or of antigens mimicking it in humans may result in autoimmune processes, as in Graves' disease. ?-Gal epitopes produced by Trypanosoma cruzi interact with anti-Gal and induce ?autoimmune like? inflammatory reactions in Chagas' disease. Anti-Gal IgM and IgG further mediate rejection of xenografts expressing ?-gal epitopes. Because of its abundance, anti-Gal may be exploited for various clinical uses. It increases immunogenicity of microbial vaccines (e.g. influenza vaccine) presenting ?-gal epitopes by targeting them for effective uptake by antigen-presenting cells. Tumour lesions are converted into vaccines against autologous tumour-associated antigens by intra-tumoral injection of ?-gal glycolipids, which insert into tumour cell membranes. Anti-Gal binding to ?-gal epitopes on tumour cells targets them for uptake by antigen-presenting cells. Accelerated wound healing is achieved by application of ?-gal nanoparticles, which bind anti-Gal, activate complement, and recruit and activate macrophages that induce tissue regeneration. This therapy may be of further significance in regeneration of internally injured tissues such as ischaemic myocardium and injured nerves. Twit Text FOAVip Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=23578170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23578170 #FOAvip English Wikipedia <ref>{{Cite pmid|23578170}}</ref> Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits #MMPMID23578170 Galili U Immunology 2013[Sep]; 140 (1): 1-11 PMID23578170show ga Anti-Gal is the most abundant natural antibody in humans, constituting ? 1% of immunoglobulins. Anti-Gal is naturally produced also in apes and Old World monkeys. The ligand of anti-Gal is a carbohydrate antigen called the ??-gal epitope? with the structure Gal?1-3Gal?1-4GlcNAc-R. The ?-gal epitope is present as a major carbohydrate antigen in non-primate mammals, prosimians and New World monkeys. Anti-Gal can contributes to several immunological pathogeneses. Anti-Gal IgE produced in some individuals causes allergies to meat and to the therapeutic monoclonal antibody cetuximab, all presenting ?-gal epitopes. Aberrant expression of the ?-gal epitope or of antigens mimicking it in humans may result in autoimmune processes, as in Graves' disease. ?-Gal epitopes produced by Trypanosoma cruzi interact with anti-Gal and induce ?autoimmune like? inflammatory reactions in Chagas' disease. Anti-Gal IgM and IgG further mediate rejection of xenografts expressing ?-gal epitopes. Because of its abundance, anti-Gal may be exploited for various clinical uses. It increases immunogenicity of microbial vaccines (e.g. influenza vaccine) presenting ?-gal epitopes by targeting them for effective uptake by antigen-presenting cells. Tumour lesions are converted into vaccines against autologous tumour-associated antigens by intra-tumoral injection of ?-gal glycolipids, which insert into tumour cell membranes. Anti-Gal binding to ?-gal epitopes on tumour cells targets them for uptake by antigen-presenting cells. Accelerated wound healing is achieved by application of ?-gal nanoparticles, which bind anti-Gal, activate complement, and recruit and activate macrophages that induce tissue regeneration. This therapy may be of further significance in regeneration of internally injured tissues such as ischaemic myocardium and injured nerves. äAnti-Gal: an abundant human natural antibody of multiple pathogeneses (epmc).pdf DeepDyve Pubget Overpricing