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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pediatr+Nephrol 2014 ; 29 (9): 1485-92 Nephropedia Template TP
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The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects #MMPMID23748364
Palanisamy A; Reeves-Daniel AM; Freedman BI
Pediatr Nephrol 2014[Sep]; 29 (9): 1485-92 PMID23748364show ga
Dramatic improvements have been seen in short term kidney allograft survival over recent decades with introduction of more potent immunosuppressant medications and regimens. Unfortunately improvements in long term graft survival have lagged behind. The genomics revolution is providing new insights regarding the potential impact of kidney donor genotypes on long term graft survival. Variation in the donor apolipoprotein L1 (APOL1), caveolin 1 (CAV1), and multi-drug resistance 1 encoding P-glycoprotein genes (ABCB1) are all associated with graft survival after kidney transplantation. Although the precise mechanisms whereby these donor gene variants confer risk for graft loss have yet to be determined, these findings provide novel opportunities for modifying interactive environmental factors and optimizing kidney allocation with the ultimate goal of improving long term graft survival rates.