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10.1002/anie.201300497

http://scihub22266oqcxt.onion/10.1002/anie.201300497
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C3800742!3800742!23650111
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suck abstract from ncbi


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pmid23650111      Angew+Chem+Int+Ed+Engl 2013 ; 52 (25): 6435-9
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  • Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability #MMPMID23650111
  • Zhang Y; Yin Q; Yin L; Ma L; Tang L; Cheng J
  • Angew Chem Int Ed Engl 2013[Jun]; 52 (25): 6435-9 PMID23650111show ga
  • Design of smart polymeric therapeutics: We designed and synthesized trigger-responsive chain-shattering polymeric therapeutics (CSPTs) via condensation polymerization of a UV-or hydrogen peroxide-responsive domain and a bisfunctional drug as co-monomers. CSPTs have precisely controlled molecular composition and unique chain-shattering type of drug release mechanism. Drug release kinetics can be precisely controlled by means of the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.
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