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10.1161/CIRCRESAHA.113.301583 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.113.301583 C3785404!3785404!23788501     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Res 2013 ; 113 (1): 9-12 Nephropedia Template TP {{tp|p=23788501|t=2013. Shedding Light on Impaired Efferocytosis and Nonresolving Inflammation |pdf=|usr=}}{{23788501}} gab.com Text Shedding Light on Impaired Efferocytosis and Nonresolving Inflammation JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=23788501 #FOAvip Nonresolving inflammation contributes to tissue damage and organ dysfunction in a wide array of pathologies, including cardiovascular disease. At the interface between inflammation and inflammation-resolution is the macrophage. Macrophage engulfment of apoptotic cells (efferocytosis) during immune cell turnover triggers activation of intra- and inter-cellular immunosuppressive signaling networks. In diseases of aging and obesity, accumulating evidence indicates that efferocytosis is impaired; the underlying mechanisms of which are unclear. In the current issue of Circulation Research, Driscoll et al., reveal that deficiency of the metalloproteinase ADAM17 prevents shedding of the apoptotic cell receptor CD36 from macrophages to enhance efferocytosis and inflammation resolution during peritonitis. These findings implicate proteolysis of apoptotic cell receptors as one explanation for defective efferocytosis-directed inflammation resolution during disease. Future studies are warranted to test the significance of these findings during cardiovascular syndromes and in other cases of nonresolving inflammation. Twit Text FOAVip Shedding Light on Impaired Efferocytosis and Nonresolving Inflammation ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=23788501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23788501 #FOAvip English Wikipedia <ref>{{Cite pmid|23788501}}</ref> Shedding Light on Impaired Efferocytosis and Nonresolving Inflammation #MMPMID23788501 Novak ML; Thorp EB Circ Res 2013[Jun]; 113 (1): 9-12 PMID23788501show ga Nonresolving inflammation contributes to tissue damage and organ dysfunction in a wide array of pathologies, including cardiovascular disease. At the interface between inflammation and inflammation-resolution is the macrophage. Macrophage engulfment of apoptotic cells (efferocytosis) during immune cell turnover triggers activation of intra- and inter-cellular immunosuppressive signaling networks. In diseases of aging and obesity, accumulating evidence indicates that efferocytosis is impaired; the underlying mechanisms of which are unclear. In the current issue of Circulation Research, Driscoll et al., reveal that deficiency of the metalloproteinase ADAM17 prevents shedding of the apoptotic cell receptor CD36 from macrophages to enhance efferocytosis and inflammation resolution during peritonitis. These findings implicate proteolysis of apoptotic cell receptors as one explanation for defective efferocytosis-directed inflammation resolution during disease. Future studies are warranted to test the significance of these findings during cardiovascular syndromes and in other cases of nonresolving inflammation. äShedding Light on Impaired Efferocytosis and Nonresolving Inflammation(epmc).pdf DeepDyve Pubget Overpricing