Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1158/0008-5472.CAN-11-1433 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-11-1433 C3782107!3782107!23633488     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2013 ; 73 (11): 3235-47 Nephropedia Template TP {{tp|p=23633488|t=2013. Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer |pdf=|usr=}}{{23633488}} gab.com Text Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23633488 #FOAvip Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here we describe a novel tumor-stroma interaction that may help explain the prevalence of desmoplasia in this cancer. Specifically, we found that activation of HIF-1? by tumor hypoxia strongly activates secretion of the sonic hedgehog ligand SHH by cancer cells which in turn causes stromal fibroblasts to increase fibrous tissue deposition. In support of this finding, elevated levels of HIF-1? and SHH in pancreatic tumors were determined to be markers of decreased patient survival. Repeated cycles of hypoxia and desmoplasia amplified each other in a feed forward loop that made tumors more aggressive and resistant to therapy. This loop could be blocked by HIF-1? inhibition, which was sufficient to block SHH production and HH signaling. Taken together, our findings suggest that increased HIF-1? produced by hypoxic tumors triggers the desmoplasic reaction in pancreatic cancer, which is then amplified by a feed forward loop involving cycles of decreased blood flow and increased hypoxia. our findings strengthen the rationale for testing HIF inhibitors may therefore represent a novel therapeutic option for pancreatic cancer. Twit Text FOAVip Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=23633488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23633488 #FOAvip English Wikipedia <ref>{{Cite pmid|23633488}}</ref> Hypoxia triggers Hedgehog-mediated tumor stromal interactions in pancreatic cancer #MMPMID23633488 Spivak-Kroizman TR; Hostetter G; Posner R; Aziz M; Hu C; Demeure MJ; Von Hoff D; Hingorani SR; Palculict TB; Izzo J; Kiriakova GM; Abdelmelek M; Bartholomeusz G; James BP; Powis G Cancer Res 2013[Jun]; 73 (11): 3235-47 PMID23633488show ga Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here we describe a novel tumor-stroma interaction that may help explain the prevalence of desmoplasia in this cancer. Specifically, we found that activation of HIF-1? by tumor hypoxia strongly activates secretion of the sonic hedgehog ligand SHH by cancer cells which in turn causes stromal fibroblasts to increase fibrous tissue deposition. In support of this finding, elevated levels of HIF-1? and SHH in pancreatic tumors were determined to be markers of decreased patient survival. Repeated cycles of hypoxia and desmoplasia amplified each other in a feed forward loop that made tumors more aggressive and resistant to therapy. This loop could be blocked by HIF-1? inhibition, which was sufficient to block SHH production and HH signaling. Taken together, our findings suggest that increased HIF-1? produced by hypoxic tumors triggers the desmoplasic reaction in pancreatic cancer, which is then amplified by a feed forward loop involving cycles of decreased blood flow and increased hypoxia. our findings strengthen the rationale for testing HIF inhibitors may therefore represent a novel therapeutic option for pancreatic cancer. äHypoxia triggers Hedgehog-mediated tumor stromal interactions in pancr(epmc).pdf DeepDyve Pubget Overpricing