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10.1016/j.immuni.2013.02.023 http://scihub22266oqcxt.onion/10.1016/j.immuni.2013.02.023 C3773956!3773956!23770227     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2013 ; 38 (6): 1164-75 Nephropedia Template TP {{tp|p=23770227|t=2013. Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation |pdf=|usr=}}{{23770227}} gab.com Text Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=23770227 #FOAvip Stromal derived follicular dendritic cells (FDCs) are a major reservoir for antigen that is essential for formation of germinal centers, the site where memory and effector B cells differentiate. A long-standing question is how FDCs retain antigen in its native form for extended periods and how they display it to specific B cells. Here we found that FDC acquired complement-coated immune complexes (IC) from non-cognate B cells via complement receptors 1 and 2 (CD35 and CD21 respectively) and rapidly internalized them by an actin-dependent pathway. IC were retained intact within a non-degradative cycling compartment and were displayed periodically on the cell surface where they were accessible to antigen-specific B cells. This would explain how antigens are protected from damage and retained over long periods of time, while remaining accessible for B cells. Twit Text FOAVip Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=23770227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23770227 #FOAvip English Wikipedia <ref>{{Cite pmid|23770227}}</ref> Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation #MMPMID23770227 Heesters BA; Chatterjee P; Kim YA; Gonzalez SF; Kuligowski MP; Kirchhausen T; Carroll MC Immunity 2013[Jun]; 38 (6): 1164-75 PMID23770227show ga Stromal derived follicular dendritic cells (FDCs) are a major reservoir for antigen that is essential for formation of germinal centers, the site where memory and effector B cells differentiate. A long-standing question is how FDCs retain antigen in its native form for extended periods and how they display it to specific B cells. Here we found that FDC acquired complement-coated immune complexes (IC) from non-cognate B cells via complement receptors 1 and 2 (CD35 and CD21 respectively) and rapidly internalized them by an actin-dependent pathway. IC were retained intact within a non-degradative cycling compartment and were displayed periodically on the cell surface where they were accessible to antigen-specific B cells. This would explain how antigens are protected from damage and retained over long periods of time, while remaining accessible for B cells. äEndocytosis and recycling of immune complexes by follicular dendritic (epmc).pdf DeepDyve Pubget Overpricing