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10.1161/ATVBAHA.112.300287 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.112.300287 C3758923!3758923!23559633     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2013 ; 33 (6): 1350-9 Nephropedia Template TP {{tp|p=23559633|t=2013. Anti-inflammatory and anti-atherogenic role of BMP Receptor II in endothelial cells |pdf=|usr=}}{{23559633}} gab.com Text Anti-inflammatory and anti-atherogenic role of BMP Receptor II in endothelial cells JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23559633 #FOAvip Objective: Atherosclerosis is an inflammatory disease with multiple underlying metabolic and physical risk factors. Bone morphogenic protein 4 (BMP4) expression is increased in endothelium in atherosclerosis-prone regions and is known to induce endothelial inflammation, endothelial dysfunction and hypertension. BMP actions are mediated by two different types of BMP receptors (BMPRI and II). Here we show a surprising finding that loss of BMPRII expression causes endothelial inflammation and atherosclerosis. Approach and Results: Using BMPRII siRNA and BMPRII+/? mice, we found that specific knockdown of BMPRII, but not other BMP receptors (Alk1,Alk2, Alk3, Alk6, ActRIIa and ActRIIb) induced endothelial inflammation in a ligand-independent manner by mechanisms mediated by reactive oxygen species (ROS), NF?B, and NADPH oxidases. Further, BMPRII+/?ApoE?/? mice developed accelerated atherosclerosis compared to BMPRII+/+ApoE?/? mice. Interestingly, we found that multiple pro-atherogenic stimuli such as hypercholesterolemia, disturbed flow (d-flow), pro-hypertensive angiotensin II (AngII), and the pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF?), downregulated BMPRII expression in endothelium, while anti-atherogenic stimuli such as stable flow (s-flow) and statin treatment upregulated its expression in vivo and in vitro. Moreover, BMPRII expression was significantly diminished in human coronary advanced atherosclerotic lesions. Also, we were able to rescue the endothelial inflammation induced by BMPRII knockdown by overexpressing the BMPRII wild-type, but not by the BMPRII short-form lacking the carboxyl-terminal tail region. Conclusions: These results suggest that BMPRII is a critical, anti-inflammatory and anti-atherogenic protein that is commonly targeted by multiple pro- and anti-atherogenic factors. BMPRII may be used as a novel diagnostic and therapeutic target in atherosclerosis. Twit Text FOAVip Anti-inflammatory and anti-atherogenic role of BMP Receptor II in endothelial cells ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23559633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23559633 #FOAvip English Wikipedia <ref>{{Cite pmid|23559633}}</ref> Anti-inflammatory and anti-atherogenic role of BMP Receptor II in endothelial cells #MMPMID23559633 Kim CW; Song H; Kumar S; Nam D; Kwon HS; Chang KH; Son DJ; Kang DW; Brodie SA; Weiss D; Vega JD; Alberts-Grill N; Griendling K; Taylor WR; Jo H Arterioscler Thromb Vasc Biol 2013[Jun]; 33 (6): 1350-9 PMID23559633show ga Objective: Atherosclerosis is an inflammatory disease with multiple underlying metabolic and physical risk factors. Bone morphogenic protein 4 (BMP4) expression is increased in endothelium in atherosclerosis-prone regions and is known to induce endothelial inflammation, endothelial dysfunction and hypertension. BMP actions are mediated by two different types of BMP receptors (BMPRI and II). Here we show a surprising finding that loss of BMPRII expression causes endothelial inflammation and atherosclerosis. Approach and Results: Using BMPRII siRNA and BMPRII+/? mice, we found that specific knockdown of BMPRII, but not other BMP receptors (Alk1,Alk2, Alk3, Alk6, ActRIIa and ActRIIb) induced endothelial inflammation in a ligand-independent manner by mechanisms mediated by reactive oxygen species (ROS), NF?B, and NADPH oxidases. Further, BMPRII+/?ApoE?/? mice developed accelerated atherosclerosis compared to BMPRII+/+ApoE?/? mice. Interestingly, we found that multiple pro-atherogenic stimuli such as hypercholesterolemia, disturbed flow (d-flow), pro-hypertensive angiotensin II (AngII), and the pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF?), downregulated BMPRII expression in endothelium, while anti-atherogenic stimuli such as stable flow (s-flow) and statin treatment upregulated its expression in vivo and in vitro. Moreover, BMPRII expression was significantly diminished in human coronary advanced atherosclerotic lesions. Also, we were able to rescue the endothelial inflammation induced by BMPRII knockdown by overexpressing the BMPRII wild-type, but not by the BMPRII short-form lacking the carboxyl-terminal tail region. Conclusions: These results suggest that BMPRII is a critical, anti-inflammatory and anti-atherogenic protein that is commonly targeted by multiple pro- and anti-atherogenic factors. BMPRII may be used as a novel diagnostic and therapeutic target in atherosclerosis. äAnti-inflammatory and anti-atherogenic role of BMP Receptor II in endo(epmc).pdf DeepDyve Pubget Overpricing