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10.1002/adma.201205088

http://scihub22266oqcxt.onion/10.1002/adma.201205088
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C3757134!3757134 !23417835
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suck abstract from ncbi


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pmid23417835
      Adv+Mater 2013 ; 25 (22 ): 3063-70
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  • Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes #MMPMID23417835
  • Yin L ; Song Z ; Kim KH ; Zheng N ; Gabrielson NP ; Cheng J
  • Adv Mater 2013[Jun]; 25 (22 ): 3063-70 PMID23417835 show ga
  • Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.
  • |Animals [MESH]
  • |Cell Membrane/*metabolism [MESH]
  • |Chitosan/chemistry [MESH]
  • |DNA/genetics [MESH]
  • |Drug Carriers/*chemistry/*metabolism [MESH]
  • |Drug Design [MESH]
  • |Hep G2 Cells [MESH]
  • |Humans [MESH]
  • |Luciferases/genetics [MESH]
  • |Mannose/*metabolism [MESH]
  • |Mice [MESH]
  • |Nanostructures/*chemistry [MESH]
  • |Plasmids/genetics [MESH]
  • |Polymers/chemistry [MESH]


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