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10.1101/cshperspect.a014258 http://scihub22266oqcxt.onion/10.1101/cshperspect.a014258 C3753723!3753723 !24003245     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24003245 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24003245 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Med 2013 ; 3 (9 ): a014258 Nephropedia Template TP {{tp|p=24003245 |t=2013. Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks |pdf=|usr=}}{{24003245 }} gab.com Text Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24003245 #FOAvip Cell growth and division require the biosynthesis of macromolecule components and cofactors (e.g., nucleotides, lipids, amino acids, and nicotinamide adenine dinucleotide phosphate [NADPH]). Normally, macromolecular biosynthesis is under tight regulatory control, yet these anabolic pathways are often dysregulated in cancer. The resulting metabolic reprogramming of cancer cells is thought to support their high rates of growth and division. The mechanisms that underlie the metabolic changes in cancer are at least partially understood, providing a rationale for their targeting with known or novel therapeutics. This review is focused on how cells sense and respond transcriptionally to essential nutrients, including glucose and glutamine, and how MAX- and MLX-centered transcription networks contribute to metabolic homeostasis in normal and neoplastic cells. Twit Text FOAVip Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24003245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24003245 #FOAvip English Wikipedia <ref>{{Cite pmid|24003245 }}</ref> Coordination of nutrient availability and utilization by MAX- and MLX-centered transcription networks #MMPMID24003245 O'Shea JM ; Ayer DE Cold Spring Harb Perspect Med 2013[Sep]; 3 (9 ): a014258 PMID24003245 show ga Cell growth and division require the biosynthesis of macromolecule components and cofactors (e.g., nucleotides, lipids, amino acids, and nicotinamide adenine dinucleotide phosphate [NADPH]). Normally, macromolecular biosynthesis is under tight regulatory control, yet these anabolic pathways are often dysregulated in cancer. The resulting metabolic reprogramming of cancer cells is thought to support their high rates of growth and division. The mechanisms that underlie the metabolic changes in cancer are at least partially understood, providing a rationale for their targeting with known or novel therapeutics. This review is focused on how cells sense and respond transcriptionally to essential nutrients, including glucose and glutamine, and how MAX- and MLX-centered transcription networks contribute to metabolic homeostasis in normal and neoplastic cells. |Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*physiology [MESH] |Basic-Leucine Zipper Transcription Factors/*physiology [MESH] |Carrier Proteins/*physiology [MESH] |Food [MESH] |G1 Phase/physiology [MESH] |Gene Regulatory Networks/*physiology [MESH] |Genes, myc/physiology [MESH] |Glucose/*physiology [MESH] |Glutamine/*physiology [MESH] |Humans [MESH] |Neoplasms/metabolism [MESH]Coordination of nutrient availability and utilization by MAX- and MLX-(epmc).pdf DeepDyve Pubget Overpricing