Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/cb400090d http://scihub22266oqcxt.onion/10.1021/cb400090d C3744587!3744587!23547844     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2013 ; 8 (6): 1283-90 Nephropedia Template TP {{tp|p=23547844|t=2013. Controllable Hydrogen Sulfide Donors and the Activity Against Myocardial Ischemia-Reperfusion Injury |pdf=|usr=}}{{23547844}} gab.com Text Controllable Hydrogen Sulfide Donors and the Activity Against Myocardial Ischemia-Reperfusion Injury JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents which could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis and biological evaluation of a new class of controllable H2S donors. Twenty five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to involve in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell-based assays to access their H2S related activities. H9c2 cardiac myocytes were used in these experiments. We tested lead donors? cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H2S related mechanism. Twit Text FOAVip Controllable Hydrogen Sulfide Donors and the Activity Against Myocardial Ischemia-Reperfusion Injury ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip English Wikipedia <ref>{{Cite pmid|23547844}}</ref> Controllable Hydrogen Sulfide Donors and the Activity Against Myocardial Ischemia-Reperfusion Injury #MMPMID23547844 Zhao Y; Bhushan S; Yang C; Otsuka H; Stein JD; Pacheco A; Peng B; Devarie-Baez NO; Aguilar HC; Lefer DJ; Xian M ACS Chem Biol 2013[Jun]; 8 (6): 1283-90 PMID23547844show ga Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents which could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis and biological evaluation of a new class of controllable H2S donors. Twenty five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to involve in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell-based assays to access their H2S related activities. H9c2 cardiac myocytes were used in these experiments. We tested lead donors? cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H2S related mechanism. äControllable Hydrogen Sulfide Donors and the Activity Against Myocardi(epmc).pdf DeepDyve Pubget Overpricing