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10.1021/cb400090d http://scihub22266oqcxt.onion/10.1021/cb400090d C3744587!3744587 !23547844     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23547844 &cmd=llinks): Failed to open stream: HTTP request failed! 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Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury |pdf=|usr=}}{{23547844 }} gab.com Text Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents that could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis, and biological evaluation of a new class of controllable H2S donors. Twenty-five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to be involved in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell-based assays to access their H2S-related activities. H9c2 cardiac myocytes were used in these experiments. We tested lead donors' cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H2S-related mechanism. Twit Text FOAVip Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23547844 #FOAvip English Wikipedia <ref>{{Cite pmid|23547844 }}</ref> Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury #MMPMID23547844 Zhao Y ; Bhushan S ; Yang C ; Otsuka H ; Stein JD ; Pacheco A ; Peng B ; Devarie-Baez NO ; Aguilar HC ; Lefer DJ ; Xian M ACS Chem Biol 2013[]; 8 (6 ): 1283-90 PMID23547844 show ga Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents that could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis, and biological evaluation of a new class of controllable H2S donors. Twenty-five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to be involved in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell-based assays to access their H2S-related activities. H9c2 cardiac myocytes were used in these experiments. We tested lead donors' cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H2S-related mechanism. |Animals [MESH] |Cell Line [MESH] |Delayed-Action Preparations/*chemistry [MESH] |Hydrogen Sulfide/*administration & dosage/therapeutic use [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myocardial Reperfusion Injury/*drug therapy [MESH]Controllable hydrogen sulfide donors and their activity against myocar(epmc).pdf DeepDyve Pubget Overpricing