Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1311865110 http://scihub22266oqcxt.onion/10.1073/pnas.1311865110 C3740880!3740880!23878236     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2013 ; 110 (32): E3037-46 Nephropedia Template TP {{tp|p=23878236|t=2013. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity |pdf=|usr=}}{{23878236}} gab.com Text Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=23878236 #FOAvip Transient Receptor Potential Melastatin 7 (TRPM7) is a divalent-permeant channel-kinase of unknown function expressed in human atrial myocytes and fibroblasts and recently implicated in atrial arrhythmias. We show that TRPM7 is highly expressed in embryonic myocardium and sinoatrial node (SAN). Trpm7 disruption in vitro, in cultured embryonic cardiomyocytes, and in vivo in zebrafish and in mice impairs cardiac automaticity. We show that this occurs via reductions in Hcn4 mRNA and the pacemaker current, If, in SAN. We conclude that TRPM7 influences diastolic membrane depolarization and automaticity in SAN via regulation of Hcn4 expression. Twit Text FOAVip Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=23878236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23878236 #FOAvip English Wikipedia <ref>{{Cite pmid|23878236}}</ref> Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity #MMPMID23878236 Sah R; Mesirca P; Van den Boogert M; Rosen J; Mably J; Mangoni ME; Clapham DE Proc Natl Acad Sci U S A 2013[Aug]; 110 (32): E3037-46 PMID23878236show ga Transient Receptor Potential Melastatin 7 (TRPM7) is a divalent-permeant channel-kinase of unknown function expressed in human atrial myocytes and fibroblasts and recently implicated in atrial arrhythmias. We show that TRPM7 is highly expressed in embryonic myocardium and sinoatrial node (SAN). Trpm7 disruption in vitro, in cultured embryonic cardiomyocytes, and in vivo in zebrafish and in mice impairs cardiac automaticity. We show that this occurs via reductions in Hcn4 mRNA and the pacemaker current, If, in SAN. We conclude that TRPM7 influences diastolic membrane depolarization and automaticity in SAN via regulation of Hcn4 expression. äIon channel-kinase TRPM7 is required for maintaining cardiac automatic(epmc).pdf DeepDyve Pubget Overpricing