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10.1164/rccm.201209-1749OC http://scihub22266oqcxt.onion/10.1164/rccm.201209-1749OC C3734612!3734612 !23590269     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23590269 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells |pdf=|usr=}}{{23590269 }} gab.com Text Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=23590269 #FOAvip RATIONALE: Natural killer (NK) cells are innate lymphocytes that target virus-infected and tumor cells. Much less is known about their ability to limit adaptive immune responses. OBJECTIVES: Thus, we investigated to what extent NK cells can influence mouse lung allograft rejection. METHODS: For this purpose, we employed an orthotopic lung transplantation model in mice. MEASUREMENTS AND MAIN RESULTS: We demonstrate here that NK cells infiltrate mouse lung allografts before T cells and thereby diminished allograft inflammation, and that NK-cell deficiency enhanced allograft rejection. In contrast, expansion of recipient NK cells through IL-15/IL-15R? complex treatment resulted in decreased T-cell infiltration and alloreactive T-cell priming as well as improved function of the allogeneic lung transplant. Only perforin-competent, but not perforin-deficient, NK cells were able to transfer these beneficial effects into transplanted NK cell-deficient IL-15R?(-/-) mice. These NK cells killed allogeneic dendritic cells (DCs) in vitro and significantly decreased the number of allogeneic DCs in transplanted lungs in vivo. Furthermore, DC-depleted lung allografts presented decreased signs of rejection. CONCLUSIONS: These results suggest that NK cells favor allograft acceptance by depleting donor-derived DCs, which otherwise would prime alloreactive T-cell responses. Thus, conditioning regimens that augment NK-cell reactivity should be clinically explored to prepare lung allograft recipients. Twit Text FOAVip Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=23590269 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23590269 #FOAvip English Wikipedia <ref>{{Cite pmid|23590269 }}</ref> Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells #MMPMID23590269 Jungraithmayr W ; Codarri L ; Bouchaud G ; Krieg C ; Boyman O ; Gyülvészi G ; Becher B ; Weder W ; Münz C Am J Respir Crit Care Med 2013[Jun]; 187 (12 ): 1349-59 PMID23590269 show ga RATIONALE: Natural killer (NK) cells are innate lymphocytes that target virus-infected and tumor cells. Much less is known about their ability to limit adaptive immune responses. OBJECTIVES: Thus, we investigated to what extent NK cells can influence mouse lung allograft rejection. METHODS: For this purpose, we employed an orthotopic lung transplantation model in mice. MEASUREMENTS AND MAIN RESULTS: We demonstrate here that NK cells infiltrate mouse lung allografts before T cells and thereby diminished allograft inflammation, and that NK-cell deficiency enhanced allograft rejection. In contrast, expansion of recipient NK cells through IL-15/IL-15R? complex treatment resulted in decreased T-cell infiltration and alloreactive T-cell priming as well as improved function of the allogeneic lung transplant. Only perforin-competent, but not perforin-deficient, NK cells were able to transfer these beneficial effects into transplanted NK cell-deficient IL-15R?(-/-) mice. These NK cells killed allogeneic dendritic cells (DCs) in vitro and significantly decreased the number of allogeneic DCs in transplanted lungs in vivo. Furthermore, DC-depleted lung allografts presented decreased signs of rejection. CONCLUSIONS: These results suggest that NK cells favor allograft acceptance by depleting donor-derived DCs, which otherwise would prime alloreactive T-cell responses. Thus, conditioning regimens that augment NK-cell reactivity should be clinically explored to prepare lung allograft recipients. |*Dendritic Cells [MESH] |Animals [MESH] |Graft Rejection/*immunology [MESH] |Interleukin-15/*immunology [MESH] |Killer Cells, Natural/*immunology [MESH] |Lung Transplantation/*immunology [MESH] |Mice [MESH]Cytokine complex-expanded natural killer cells improve allogeneic lung(epmc).pdf DeepDyve Pubget Overpricing