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2013 ; 7
(6
): 4967-76
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Three-dimensional hierarchical plasmonic nano-architecture enhanced
surface-enhanced Raman scattering immunosensor for cancer biomarker detection in
blood plasma
#MMPMID23659430
Li M
; Cushing SK
; Zhang J
; Suri S
; Evans R
; Petros WP
; Gibson LF
; Ma D
; Liu Y
; Wu N
ACS Nano
2013[Jun]; 7
(6
): 4967-76
PMID23659430
show ga
A three-dimensional (3D) hierarchical plasmonic nano-architecture has been
designed for a sensitive surface-enhanced Raman scattering (SERS) immunosensor
for protein biomarker detection. The capture antibody molecules are immobilized
on a plasmonic gold triangle nanoarray pattern. On the other hand, the detection
antibody molecules are linked to the gold nanostar@Raman reporter@silica sandwich
nanoparticles. When protein biomarkers are present, the sandwich nanoparticles
are captured over the gold triangle nanoarray, forming a confined 3D plasmonic
field, leading to the enhanced electromagnetic field in intensity and in 3D
space. As a result, the Raman reporter molecules are exposed to a high density of
"hot spots", which amplifies the Raman signal remarkably, improving the
sensitivity of the SERS immunosensor. This SERS immunosensor exhibits a wide
linear range (0.1 pg/mL to 10 ng/mL) and a low limit of detection (7 fg/mL)
toward human immunoglobulin G protein in the buffer solution. This biosensor has
been successfully used for detection of the vascular endothelial growth factor in
the human blood plasma from clinical breast cancer patient samples.
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