Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.stem.2013.04.013 http://scihub22266oqcxt.onion/10.1016/j.stem.2013.04.013 C3725985!3725985 !23665121     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23665121 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2013 ; 12 (6 ): 699-712 Nephropedia Template TP {{tp|p=23665121 |t=2013. Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming |pdf=|usr=}}{{23665121 }} gab.com Text Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=23665121 #FOAvip The chromatin state of pluripotency genes has been studied extensively in embryonic stem cells (ESCs) and differentiated cells, but their potential interactions with other parts of the genome remain largely unexplored. Here, we identified a genome-wide, pluripotency-specific interaction network around the Nanog promoter by adapting circular chromosome conformation capture sequencing. This network was rearranged during differentiation and restored in induced pluripotent stem cells. A large fraction of Nanog-interacting loci were bound by Mediator or cohesin in pluripotent cells. Depletion of these proteins from ESCs resulted in a disruption of contacts and the acquisition of a differentiation-specific interaction pattern prior to obvious transcriptional and phenotypic changes. Similarly, the establishment of Nanog interactions during reprogramming often preceded transcriptional upregulation of associated genes, suggesting a causative link. Our results document a complex, pluripotency-specific chromatin "interactome" for Nanog and suggest a functional role for long-range genomic interactions in the maintenance and induction of pluripotency. Twit Text FOAVip Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=23665121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23665121 #FOAvip English Wikipedia <ref>{{Cite pmid|23665121 }}</ref> Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming #MMPMID23665121 Apostolou E ; Ferrari F ; Walsh RM ; Bar-Nur O ; Stadtfeld M ; Cheloufi S ; Stuart HT ; Polo JM ; Ohsumi TK ; Borowsky ML ; Kharchenko PV ; Park PJ ; Hochedlinger K Cell Stem Cell 2013[Jun]; 12 (6 ): 699-712 PMID23665121 show ga The chromatin state of pluripotency genes has been studied extensively in embryonic stem cells (ESCs) and differentiated cells, but their potential interactions with other parts of the genome remain largely unexplored. Here, we identified a genome-wide, pluripotency-specific interaction network around the Nanog promoter by adapting circular chromosome conformation capture sequencing. This network was rearranged during differentiation and restored in induced pluripotent stem cells. A large fraction of Nanog-interacting loci were bound by Mediator or cohesin in pluripotent cells. Depletion of these proteins from ESCs resulted in a disruption of contacts and the acquisition of a differentiation-specific interaction pattern prior to obvious transcriptional and phenotypic changes. Similarly, the establishment of Nanog interactions during reprogramming often preceded transcriptional upregulation of associated genes, suggesting a causative link. Our results document a complex, pluripotency-specific chromatin "interactome" for Nanog and suggest a functional role for long-range genomic interactions in the maintenance and induction of pluripotency. |Animals [MESH] |Cellular Reprogramming/*genetics [MESH] |Chromatin/*genetics/*metabolism [MESH] |Genome/*genetics [MESH] |Homeodomain Proteins/*genetics/metabolism [MESH] |Humans [MESH] |Mice [MESH] |Nanog Homeobox Protein [MESH]Genome-wide chromatin interactions of the Nanog locus in pluripotency,(epmc).pdf DeepDyve Pubget Overpricing