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10.1021/nn4012384 http://scihub22266oqcxt.onion/10.1021/nn4012384 C3718078!3718078!23647441     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Nano 2013 ; 7 (6): 5376-84 Nephropedia Template TP {{tp|p=23647441|t=2013. A Highly Efficient Synthetic Vector: Non-Hydrodynamic Delivery of DNA to Hepatocyte Nuclei In Vivo |pdf=|usr=}}{{23647441}} gab.com Text A Highly Efficient Synthetic Vector: Non-Hydrodynamic Delivery of DNA to Hepatocyte Nuclei In Vivo JO: ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=23647441 #FOAvip Multifunctional membrane-core nanoparticles, composed of calcium phosphate cores, arginine-rich peptides, cationic and PEGylated lipid membranes, and galactose targeting ligands, have been developed as synthetic vectors for efficient nuclear delivery of plasmid DNA and subsequent gene expression in hepatocytes in vivo. Targeted particles exhibited rapid and extensive hepatic accumulation and were predominantly internalized by hepatocytes, while the inclusion of such peptides in LCP was sufficient to elicit high degrees of nuclear translocation of plasmid DNA. Monocyclic CR8C significantly enhanced in vivo gene expression over ten-fold more than linear CR8C, likely due to a release-favoring mechanism of the DNA/peptide complex. Though 100-fold lower in activity than that achieved via hydrodynamic injection, this formulation presents as a much less invasive alternative. To our knowledge, this is the most effective synthetic vector for liver gene transfer. Twit Text FOAVip A Highly Efficient Synthetic Vector: Non-Hydrodynamic Delivery of DNA to Hepatocyte Nuclei In Vivo ????ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=23647441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23647441 #FOAvip English Wikipedia <ref>{{Cite pmid|23647441}}</ref> A Highly Efficient Synthetic Vector: Non-Hydrodynamic Delivery of DNA to Hepatocyte Nuclei In Vivo #MMPMID23647441 Hu Y; Haynes MT; Wang Y; Liu F; Huang L ACS Nano 2013[Jun]; 7 (6): 5376-84 PMID23647441show ga Multifunctional membrane-core nanoparticles, composed of calcium phosphate cores, arginine-rich peptides, cationic and PEGylated lipid membranes, and galactose targeting ligands, have been developed as synthetic vectors for efficient nuclear delivery of plasmid DNA and subsequent gene expression in hepatocytes in vivo. Targeted particles exhibited rapid and extensive hepatic accumulation and were predominantly internalized by hepatocytes, while the inclusion of such peptides in LCP was sufficient to elicit high degrees of nuclear translocation of plasmid DNA. Monocyclic CR8C significantly enhanced in vivo gene expression over ten-fold more than linear CR8C, likely due to a release-favoring mechanism of the DNA/peptide complex. Though 100-fold lower in activity than that achieved via hydrodynamic injection, this formulation presents as a much less invasive alternative. To our knowledge, this is the most effective synthetic vector for liver gene transfer. äA Highly Efficient Synthetic Vector: Non-Hydrodynamic Delivery of DNA (epmc).pdf DeepDyve Pubget Overpricing